Cooperative Rh(II)/Pd(0) Dual-Catalyzed gem-Difunctionalization of α-Diazo Carbonyl Compounds: Construction of Quaternary Carbon Centers,European Journal of Organic Chemistry

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Cooperative Rh(II)/Pd(0) Dual-Catalyzed gem-Difunctionalization of α-Diazo Carbonyl Compounds: Construction of Quaternary Carbon Centers
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-05-24 , DOI: 10.1002/ejoc.202200499
Zi Xuan ₁ , zi-sheng chen ₂

Affiliation

Efficient construction of quaternary carbon centers is one of the great challenges in organic synthesis. Recent advances in cooperative Rh(II)/Pd(0) dual catalysis that promote the reactions of stable α-diazo-β-keto-esters (acceptor/acceptor) with allylic carboxylates are summarized. In this process, the catalytically generated Rh(II)-carbenoids (A) and π-allyl Pd(II) intermediates (B) are involved. Various all- and O-substituted quaternary carbon centers can be efficiently constructed, in which two bonds at the carbenic center were formed in a straightforward manner.

中文翻译：

α-重氮羰基化合物的Rh(II)/Pd(0)双催化双官能团化：季碳中心的构建

季碳中心的高效构建是有机合成面临的巨大挑战之一。总结了促进稳定的α-重氮-β-酮酯（受体/受体）与烯丙基羧酸盐反应的协同Rh(II)/Pd(0)双催化的最新进展。在这个过程中，涉及到催化生成的 Rh(II)-carbenoids ( A ) 和π-烯丙基 Pd(II) 中间体 ( B )。可以有效地构建各种全取代和O取代的季碳中心，其中碳本中心的两个键以简单的方式形成。

更新日期：2022-05-24

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