Pseudorabies virus (PRV) is a double-stranded DNA virus with a genome approximating 150 kb in size. PRV contains many non-essential genes that can be replaced with genes encoding heterogenous antigens without affecting viral propagation. With the ability to induce cellular, humoral and mucosal immune responses in the host, PRV is considered to be an ideal and potential live vector for generation of animal vaccines. In this review, we summarize the advances in attenuated recombinant PRVs and design of PRV-based live vaccines as well as the challenge of vaccine application.

中文翻译：

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基于伪狂犬病病毒平台的动物减毒活疫苗设计

伪狂犬病病毒 (PRV) 是一种双链 DNA 病毒，基因组大小约为 150 kb。PRV 包含许多非必需基因，这些基因可以被编码异源抗原的基因替代，而不影响病毒传播。由于能够在宿主体内诱导细胞、体液和黏膜免疫反应，PRV 被认为是生产动物疫苗的理想和潜在的活载体。在这篇综述中，我们总结了减毒重组 PRV 的进展和基于 PRV 的活疫苗的设计以及疫苗应用的挑战。