Bone regeneration during treatment of staphylococcal bone infection is challenging due to the ability of Staphylococcus aureus to invade and persist within osteoblasts. Here, we sought to determine whether the metabolic and extracellular organic matrix formation and mineralization ability of S. aureus-infected human osteoblasts can be restored after rifampicin (RMP) therapy.

中文翻译：

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利福平在细胞内金黄色葡萄球菌感染后恢复细胞外有机基质的形成和成骨细胞的矿化。

由于金黄色葡萄球菌能够侵入并在成骨细胞内持续存在，因此在治疗葡萄球菌性骨感染期间的骨再生具有挑战性。在这里，我们试图确定在利福平 (RMP) 治疗后是否可以恢复金黄色葡萄球菌感染的人类成骨细胞的代谢和细胞外有机基质形成和矿化能力。