We report a photoinduced iron catalysis for the efficient C–C bond cleavage and bromination or iodination of unstrained tertiary cycloalkanols with NBS/NIS. The reaction features good functional group tolerance and high yields under mild conditions and provides a powerful tool for the preparation of remote halogenated alkyl ketones. The products can be converted via nucleophilic substitution or cross-coupling to other valuable molecules, such as haloperidol, fluanisone, and azabuperone, demonstrating the synthetic value of this reaction.

中文翻译：

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光诱导 Fe 催化无应变环醇的溴化和碘化

我们报告了用 NBS/NIS 对未应变的叔环烷醇进行有效的 C-C 键断裂和溴化或碘化​​的光诱导铁催化。该反应在温和条件下具有良好的官能团耐受性和高收率，为远程卤代烷基酮的制备提供了有力的工具。产物可以通过亲核取代或交叉偶联转化为其他有价值的分子，如氟哌啶醇、氟苯尼松和氮杂苯哌酮，证明了该反应的合成价值。