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Resveratrol Attenuates Mast Cell Mediated Allergic Reactions: Potential for Use as a Nutraceutical in Allergic Diseases?
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-05-22 , DOI: 10.1002/mnfr.202200170
Mehtap Civelek 1 , Sabrina Bilotta 1 , Axel Lorentz 1
Affiliation  

Allergic diseases are one of the most common health disorders affecting about 30% of the world population. Mast cells (MCs) are key effector cells of allergic reactions by releasing proinflammatory mediators including histamine, lipid mediators, and cytokines/chemokines. Natural substances like secondary plant substances such as resveratrol (RESV), which can contribute to prevention and treatment of diseases, are becoming increasingly interesting for use as nutraceuticals. In this review, the anti-inflammatory effects of RESV on MC-mediated allergic reactions in vitro and in vivo models are summarized. The studies indicate that RESV inhibits MC degranulation, synthesis of arachidonic acid metabolites, expression of cytokines and chemokines as well as activation of signal molecules involved in proinflammatory mechanisms. Also, beneficial impacts by this polyphenol are reported in randomized controlled trials with allergic rhinitis patients. Although it cannot yet be concluded that RESV can be used successfully in allergy patients in general, there are many results that indicate a possible role for RESV for use as an anti-inflammatory nutraceutical. However, strategies to favorably influence the poor bioavailability of RESV would be helpful.

中文翻译:

白藜芦醇减弱肥大细胞介导的过敏反应:有可能用作过敏性疾病的营养品?

过敏性疾病是影响世界约 30% 人口的最常见的健康疾病之一。肥大细胞 (MC) 通过释放促炎介质(包括组胺、脂质介质和细胞因子/趋化因子)是过敏反应的关键效应细胞。诸如白藜芦醇 (RESV) 等可有助于预防和治疗疾病的天然物质在用作营养保健品方面正变得越来越有趣。本综述总结了RESV在体外和体内模型中对MC介导的过敏反应的抗炎作用。研究表明,RESV 抑制 MC 脱粒、花生四烯酸代谢物的合成、细胞因子和趋化因子的表达以及参与促炎机制的信号分子的激活。还,在过敏性鼻炎患者的随机对照试验中报告了这种多酚的有益影响。虽然目前还不能得出结论,RESV 可以成功地用于一般过敏患者,但有许多结果表明 RESV 可能用作抗炎保健品。然而,有利地影响 RESV 较差的生物利用度的策略将是有帮助的。
更新日期:2022-05-22
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