Controlling kinase inhibitors’ residence time via reversible covalent binding is of high interest in drug discovery. Tuning reversible covalent binding kinetics using a pan-kinase inhibitor that reacts with the catalytic lysine enabled exquisite temporal selectivity in vitro and in vivo.

中文翻译：

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调出

通过可逆共价结合控制激酶抑制剂的停留时间在药物发现中具有很高的意义。使用与催化赖氨酸反应的泛激酶抑制剂调整可逆共价结合动力学，可以在体外和体内实现精确的时间选择性。