The combination of 2D MXenes with high affinity aptamers has resulted in the development of innovative aptasensing approaches for food/water safety and clinical diagnosis. Aptamers have quite a number of benefits over conventional methods as unique molecular recognition components for versatile bio-sensing devices. Recent breakthroughs in the concept, development, and bio-sensing applications of various MXene-based aptasensors have been discussed in this study. The authors address sensing platforms for the identification of several types of cancers, mycotoxins, and other analytes. More emphasis has been placed on aptamer conjugation with various MXenes, sensor fabrication methodologies, and biosensing mechanisms. We observed that optical aptasensing applications are in their infancy when compared to electrochemical MXene based aptasensors. As a result, we attempted to forecast revolutionary developments in MXenes that may contribute to their integration into emerging optical aptasensors such as fluorescence, photoluminescence, surface-enhanced Raman Scattering, colorimetric, and Surface Plasmon Resonance. Finally, potential constraints and future prospects have been highlighted. This study is expected to help readers understand the fabrication of MXene-based aptasensors and their concomitant sensing mechanisms, hence encouraging the development of flexible MXene-based aptasensors.

2D MXenes 与高亲和力适配体的结合促成了用于食品/水安全和临床诊断的创新适配传感方法的开发。作为通用生物传感设备的独特分子识别组件，适配体与传统方法相比具有许多优势。本研究讨论了各种基于 MXene 的适体传感器在概念、开发和生物传感应用方面的最新突破。作者介绍了用于识别几种癌症、霉菌毒素和其他分析物的传感平台。更多的重点放在了与各种 MXenes、传感器制造方法和生物传感机制的适体缀合上。我们观察到，与基于电化学 MXene 的适体传感器相比，光学适体传感应用还处于起步阶段。因此，我们试图预测 MXenes 的革命性发展，这可能有助于它们集成到新兴的光学适体传感器中，例如荧光、光致发光、表面增强拉曼散射、比色和表面等离子体共振。最后，强调了潜在的制约因素和未来前景。该研究有望帮助读者了解基于 MXene 的适体传感器的制造及其伴随的传感机制，从而鼓励开发基于 MXene 的柔性适体传感器。强调了潜在的制约因素和未来前景。这项研究有望帮助读者了解基于 MXene 的适体传感器的制造及其伴随的传感机制，从而鼓励开发基于 MXene 的柔性适体传感器。强调了潜在的制约因素和未来前景。这项研究有望帮助读者了解基于 MXene 的适体传感器的制造及其伴随的传感机制，从而鼓励开发基于 MXene 的柔性适体传感器。