Burden of osteoarthritis in India and its states, 1990–2019: findings from the Global Burden of disease study 2019,Osteoarthritis and Cartilage

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Burden of osteoarthritis in India and its states, 1990–2019: findings from the Global Burden of disease study 2019
Osteoarthritis and Cartilage ( IF 7.2 ) Pub Date : 2022-05-19 , DOI: 10.1016/j.joca.2022.05.004
A Singh ₁ , S Das ₂ , A Chopra ₃ , D Danda ₄ , B J Paul ₅ , L March ₆ , A J Mathew ₇ , P Shenoy ₈ , C Gotay ₉ , A J Palmer ₁ , B Antony ₁

Affiliation

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Era's University, Lucknow, India.
Centre for Rheumatic Diseases, Apollo Jehangir Hospital, Pune University, Pune, India.
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India.
Department of General Medicine, KMCT Medical College, Calicut, Kerala, India.
Institute of Bone and Joint Research, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia; Florance and Cope Professorial Rheumatology Department, University of Sydney Royal North Shore Hospital, St Leonards, Sydney, Australia.
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Copenhagen University Hospital - Rigshospitalet Glostrup, Denmark.
Centre for Arthritis & Rheumatism Excellence, Kochi, Kerala, India.
University of British Columbia, Vancouver, BC Canada.

Objective

To describe the burden of osteoarthritis (OA) in India from 1990 to 2019.

Design

Data from Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 were used. The burden of OA –knee OA, hip OA, hand OA, and other OA– was estimated for India and its states from 1990 to 2019 through a systematic analysis of prevalence, incidence, years lived with disability (YLD), and disability-adjusted life years (DALY) using methods reported in GBD 2019 study.

Result

Around 23.46 million individuals in India had OA in 1990; this increased to 62.35 million in 2019. The age-standardised prevalence of OA increased from 4,895 (95% uncertainty interval (UI):4,420–5,447) in 1990–5313 (95%UI:4,799–5,898) in 2019, per 100,000 persons. Similarly, DALYs due to OA increased from 0.79 million (95%UI:0.40–1.55) to 2.12 million (95%UI:1.07–4.23); while age-standardised DALYs increased from 164 (95%UI:83–325) to 180 (95%UI:91–361) per 100,000 persons from 1990 to 2019. OA was the 20^th most common cause of YLDs in India in 2019, accounting for 1.48% (95%UI:0.88–2.78) of all YLDs; increasing from 23rd most common cause in 1990 (1.25%(95%UI:0.74–2.34)). Knee OA was the most common form of OA, followed by hand OA. The prevalence, incidence, and DALYs for OA and knee OA were consistently higher in females than males.

Conclusion

The burden and impact of OA in India are substantial and is increasing. Adopting suitable control and preventive community measures to reduce modifiable risk factors (obesity, injuries, occupational stress) are needed to reduce the current and future burden of OA in India.

中文翻译：

1990-2019 年印度及其各邦的骨关节炎负担：2019 年全球疾病负担研究的结果

客观的

描述 1990 年至 2019 年印度骨关节炎 (OA) 的负担。

设计

使用了 2019 年全球疾病负担、伤害和风险因素研究 (GBD) 的数据。通过对患病率、发病率、残疾寿命 (YLD) 和残疾调整后的系统分析，估计了 1990 年至 2019 年印度及其各州的 OA 负担——膝关节 OA、髋部 OA、手部 OA 和其他 OA使用 GBD 2019 研究中报告的方法的生命年 (DALY)。

结果

1990 年印度约有 2346 万人患有 OA；这在 2019 年增加到 6235 万。OA 的年龄标准化患病率从 1990 年的 4,895（95% 不确定区间 (UI)：4,420–5,447）增加到 2019 年的 5313（95%UI：4,799–5,898），每 100,000 人. 同样，OA 导致的 DALY 从 79 万（95%UI：0.40-1.55）增加到 212 万（95%UI：1.07-4.23）；而从 1990 年到 2019 年，年龄标准化的 DALYs 从每 100,000 人的 164 (95%UI:83–325) 增加到 180 (95%UI:91–361)。OA 是第 20^位2019 年印度 YLD 的最常见原因，占所有 YLD 的 1.48%（95%UI：0.88–2.78）；从 1990 年的第 23 位最常见原因 (1.25%(95%UI:0.74–2.34)) 增加。膝关节 OA 是最常见的 OA 形式，其次是手部 OA。女性 OA 和膝关节 OA 的患病率、发病率和 DALYs 始终高于男性。