Objectives

The aim of this systematic review was to assess the effects of stem cell-based therapies on the treatment of Temporomandibular Joint Osteoarthritis (TMJ-OA) and the regeneration of cartilage/osteochondral defects.

Methods

Data on preclinical studies evaluating the effectiveness of stem cell-based therapies for treating Temporomandibular Disorders (TMDs) were extracted from PubMed, Web of Science, and Cochrane Library and the grey literature by three independent reviewers. A manual search was performed in the databases, the reference list of review studies, and relevant journals in the field. Compliance with the ARRIVE guidelines was evaluated for quality assessment. SYRCLE's risk of bias tool for animal experimental studies was assessed to define internal validity.

Results

After applying the inclusion and exclusion criteria, 10 studies were included in the qualitative synthesis. Regardless of cell origin, stem cell-based therapeutic approaches induced protective, anti-inflammatory, and chondroregenerative potential in the treatment of TMJ-OA. Regeneration of the cartilage layer on the surface of the condyle was achieved when stem cells were directly flushed into the defect or when delivered within a carrier.

Conclusion

Stem cell-based therapies may be considered a promising approach for the treatment of TMJ-OA and for the regeneration of full-thickness cartilage and osteochondral defects in the TMJ. Human studies shall be performed to validate these results found in animals.

中文翻译：

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基于干细胞的颞下颌关节骨关节炎和软骨/骨软骨缺损再生疗法：临床前实验的系统评价

目标

本系统评价的目的是评估基于干细胞的疗法对治疗颞下颌关节骨关节炎 (TMJ-OA) 和软骨/骨软骨缺损再生的效果。

方法

三位独立评审员从 PubMed、Web of Science 和 Cochrane 图书馆和灰色文献中提取了评估基于干细胞的疗法治疗颞下颌关节紊乱病 (TMD) 有效性的临床前研究数据。在数据库、评论研究的参考列表和该领域的相关期刊中进行了手动搜索。对 ARRIVE 指南的遵守情况进行了质量评估。SYRCLE 用于动物实验研究的偏倚风险工具被评估以定义内部有效性。

结果

应用纳入和排除标准后，定性综合纳入10项研究。无论细胞来源如何，基于干细胞的治疗方法在 TMJ-OA 治疗中均具有保护、抗炎和软骨再生的潜力。当干细胞直接冲入缺损处或在载体内递送时，可以实现髁突表面软骨层的再生。

结论

基于干细胞的疗法可能被认为是治疗 TMJ-OA 和 TMJ 中全层软骨和骨软骨缺损再生的有前景的方法。应进行人体研究以验证在动物中发现的这些结果。