Patients undergoing knee surgery are at high risk for deep vein thrombosis (DVT), which is infrequent but potentially life-threatening. It has not been identified how to efficiently detect high-risk DVT while minimizing bleeding complications from anticoagulation. We hypothesized that the degree of activation of thrombotic markers may correlate with the size of the thrombus. Therefore, we investigated the correlation between thrombotic markers and DVT thrombus volume in patients after knee surgery. This retrospective study involved 29 patients who underwent around knee osteotomy or total / unicompartmental knee arthroplasty from 2018 to 2020. Fibrin monomer complex (FMC) at 1, and 7 days after surgery, and D-dimer at 4, and 7 days after surgery were investigated. In addition, the volume of DVT was estimated with ultrasonography at the 7 days after surgery. Body mass index, surgical time, and total volume of blood loss were also evaluated. Factors related to thrombus volume were examined statistically. Nine patients (31.0%) exhibited asymptomatic distal DVT, whereas 1 patient (3.4%) experienced asymptomatic proximal DVT. No patients had pulmonary embolism. Statistical analysis showed that only FMC concentration on postoperative day 1 was significantly correlated with thrombus volume (p < 0.001, 95% confidence interval 0.41 to 0.839, r = 0.679). The FMC concentration was a useful early indicator of deep vein thrombosis after knee surgery. Monitoring the FMC concentration could enable selective identification of patients with a high thrombus volume, which is associated with a high risk for pulmonary embolism.

中文翻译：

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术后第1天的纤维蛋白单体复合物与膝关节手术后深静脉血栓的体积相关

接受膝关节手术的患者发生深静脉血栓 (DVT) 的风险很高，这种情况很少见，但可能危及生命。目前尚未确定如何有效检测高风险 DVT，同时最大限度地减少抗凝引起的出血并发症。我们假设血栓标志物的激活程度可能与血栓的大小相关。因此，我们研究了膝关节术后患者血栓标志物与 DVT 血栓体积的相关性。这项回顾性研究涉及 2018 年至 2020 年接受膝关节周围截骨术或全/单间室膝关节置换术的 29 名患者。调查了。此外，术后7天通过超声检查估计DVT的体积。还评估了体重指数、手术时间和失血总量。对与血栓体积相关的因素进行统计学检查。9 名患者 (31.0%) 表现出无症状远端 DVT，而 1 名患者 (3.4%) 表现出无症状近端 DVT。无患者发生肺栓塞。统计分析显示，仅术后第1天的FMC浓度与血栓体积显着相关（p < 0.001，95%置信区间0.41至0.839，r = 0.679）。FMC 浓度是膝关节手术后深静脉血栓形成的有用早期指标。监测 FMC 浓度可以选择性识别高血栓量患者，而高血栓量与肺栓塞的高风险相关。