Dietary Exosome-Like Nanoparticles: An Updated Review on Their Pharmacological and Drug Delivery Applications,Molecular Nutrition & Food Research

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Dietary Exosome-Like Nanoparticles: An Updated Review on Their Pharmacological and Drug Delivery Applications
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-05-20 , DOI: 10.1002/mnfr.202200142
Rajitha Anusha _{1,

2} , Sulochana Priya _{1,

2}

Affiliation

Exosomes are lipid bilayer membrane-bound extracellular vesicular structures (30–150 nm) mainly released by eukaryotic cells of animal origin. Exosome-like nanoparticles (ELNs) are the vesicular structures originating from plant sources with features similar to eukaryotic animal cell derived exosomes. ELNs derived from dietary sources (dietary ELNs) have exceptional pharmacological potential in alleviating many diseases and are good in maintaining intestinal health through the manipulation of the gut microbiome. The dietary ELNs being highly biocompatible find their application in targeted therapy as well. They are being established as promising drug delivery agents and can also be developed into dietary supplements. This review highlights the ELNs derived from various dietary sources, their diversity in molecular compositions, potential health benefits, and drug delivery applications. Few clinical trials are attempted with dietary ELNs which are also described in the review along with their properties that can be exploited for the food and pharma industries in the future.

中文翻译：

膳食外泌体样纳米颗粒：对其药理学和药物递送应用的最新评论

外泌体是脂质双层膜结合的细胞外囊泡结构（30-150 nm），主要由动物来源的真核细胞释放。外泌体样纳米颗粒 (ELN) 是源自植物的囊泡结构，其特征类似于真核动物细胞衍生的外泌体。来源于膳食来源的 ELNs（膳食 ELNs）在缓解许多疾病方面具有非凡的药理潜力，并且通过操纵肠道微生物组有利于维持肠道健康。具有高度生物相容性的膳食 ELNs 也发现它们在靶向治疗中的应用。它们正在被确立为有前途的药物输送剂，也可以开发成膳食补充剂。这篇综述强调了来自各种饮食来源的 ELN，它们在分子组成方面的多样性，潜在的健康益处和药物输送应用。很少有人尝试对膳食 ELN 进行临床试验，评论中也描述了这些 ELN 以及它们未来可用于食品和制药行业的特性。

更新日期：2022-05-20

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