How is the brain so efficient at excluding proteins, drugs, and immune cells from the blood? In this issue of Neuron, Ayloo et al. (2022) find that an extracellular matrix protein secreted by CNS pericytes shuts down endocytic transport in blood brain barrier endothelial cells.

中文翻译：

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基质蛋白堵洞：周细胞如何抑制血脑屏障转胞吞作用

大脑为何如此有效地从血液中排除蛋白质、药物和免疫细胞？在本期 Neuron 中，Ayloo 等人。(2022) 发现 CNS 周细胞分泌的细胞外基质蛋白会关闭血脑屏障内皮细胞的内吞转运。