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Retinal Findings of Hospitalized Neonates Recovered from COVID-19 Infection: A Prospective, Observational, Descriptive Study
Journal of Tropical Pediatrics ( IF 1.8 ) Pub Date : 2022-05-18 , DOI: 10.1093/tropej/fmac036
Filiz Aktürk Acar 1 , Mahmut Cenap Esenülkü 2 , Berna Hekimoğlu 1
Affiliation  

Purpose Coronavirus disease 2019 (COVID-19) that is caused by severe acute respiratory syndrome coronavirus 2 can cause microvascular alterations that can lead to irreversible complications in multiple tissues and organs. Detrimental effects of COVID-19 on retinal structure have recently been reported in adult population. However, literature data about neonatal population is very scarce. Thus, we aimed to assess possible retinal changes of neonates recovered from COVID-19 infection in this prospective, observational, descriptive study. Methods The neonates recovered from COVID-19 infection were included to the study between 01 September 2020 and 30 April 2021. Their initial ophthalmological examination was made after a negative real-time reverse transcription-polymerase chain reaction obtained and all patients were re-examined 1 month later. All examinations were performed by same retina specialist using a binocular indirect ophthalmoscopy. Results A total of 15 neonates [9 (60%) male, 6 (40%) female, mean gestational age of 38.9 ± 0.9 weeks (ranging from 37 to 40 week)] were evaluated in the study. The mean age at the time of hospitalization was 17.5 ± 8.7 days (ranging from 2 to 29 days), and the mean duration of hospitalization was 12.5 ± 6.2 days (ranging from 4 to 27 days). Except for one patient with bilateral avascular area in Zone-III, no further retinal manifestation related to COVID-19 was found in the study. Conclusion COVID-19 infection can cause retinal damage in neonates. Therefore, these patients should be closely monitored for signs of ocular involvement.

中文翻译:

从 COVID-19 感染中恢复的住院新生儿的视网膜发现:一项前瞻性、观察性、描述性研究

目的 由严重急性呼吸综合征冠状病毒 2 引起的 2019 年冠状病毒病 (COVID-19) 可引起微血管改变,从而导致多个组织和器官出现不可逆转的并发症。最近在成年人群中报道了 COVID-19 对视网膜结构的不利影响。然而,关于新生儿人口的文献数据非常稀缺。因此,我们旨在在这项前瞻性、观察性、描述性研究中评估从 COVID-19 感染中恢复的新生儿可能的视网膜变化。方法 2020 年 9 月 1 日至 2021 年 4 月 30 日期间,从 COVID-19 感染中康复的新生儿纳入研究。在获得阴性实时逆转录聚合酶链反应后,对他们进行初步眼科检查,并对所有患者进行重新检查 1一个月后。所有检查均由同一位视网膜专家使用双眼间接检眼镜进行。结果本研究共评估了 15 名新生儿 [9 (60%) 名男性,6 (40%) 名女性,平均胎龄为 38.9 ± 0.9 周(37 至 40 周)]。住院时的平均年龄为 17.5 ± 8.7 天(范围为 2 至 29 天),平均住院时间为 12.5 ± 6.2 天(范围为 4 至 27 天)。除一名患者在三区双侧无血管区外,研究中未发现与 COVID-19 相关的进一步视网膜表现。结论 COVID-19感染可引起新生儿视网膜损伤。因此,应密切监测这些患者的眼部受累迹象。结果本研究共评估了 15 名新生儿 [9 (60%) 名男性,6 (40%) 名女性,平均胎龄为 38.9 ± 0.9 周(37 至 40 周)]。住院时的平均年龄为 17.5 ± 8.7 天(范围为 2 至 29 天),平均住院时间为 12.5 ± 6.2 天(范围为 4 至 27 天)。除一名患者在三区双侧无血管区外,研究中未发现与 COVID-19 相关的进一步视网膜表现。结论 COVID-19感染可引起新生儿视网膜损伤。因此,应密切监测这些患者的眼部受累迹象。结果本研究共评估了 15 名新生儿 [9 (60%) 名男性,6 (40%) 名女性,平均胎龄为 38.9 ± 0.9 周(37 至 40 周)]。住院时的平均年龄为 17.5 ± 8.7 天(范围为 2 至 29 天),平均住院时间为 12.5 ± 6.2 天(范围为 4 至 27 天)。除一名患者在三区双侧无血管区外,研究中未发现与 COVID-19 相关的进一步视网膜表现。结论 COVID-19感染可引起新生儿视网膜损伤。因此,应密切监测这些患者的眼部受累迹象。7天(2~29天),平均住院时间12.5±6.2天(4~27天)。除一名患者在三区双侧无血管区外,研究中未发现与 COVID-19 相关的进一步视网膜表现。结论 COVID-19感染可引起新生儿视网膜损伤。因此,应密切监测这些患者的眼部受累迹象。7天(2~29天),平均住院时间12.5±6.2天(4~27天)。除一名患者在三区双侧无血管区外,研究中未发现与 COVID-19 相关的进一步视网膜表现。结论 COVID-19感染可引起新生儿视网膜损伤。因此,应密切监测这些患者的眼部受累迹象。
更新日期:2022-05-18
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