Background CT-scan measures of muscle composition may be associated with recovery post hip fracture. Methods In an ancillary study to Baltimore Hip Studies 7th cohort, older adults were evaluated at 2 and 6 months post-hip fracture. CT-scan measures of muscle were acquired at 2 months. Short Physical Performance Battery (SPPB) was measured at 2 and 6 months. Generalized estimating equations were used to model the association of muscle measures and physical function, adjusting for age, sex, BMI, and time post fracture. Results Seventy-one older adults (52% males, age 79.6 ± 7.3 yrs) were included. At 2-months, males had greater thigh cross-sectional area (CSA, p<0.0001) and less low density muscle (p=0.047), and intermuscular adipose tissue (p=0.007) than females on the side of the fracture, while females performed better on the SPPB (p= 0.05). Muscle measures on the fractured side were associated with function at 2 months in both sexes. Subjects in the lowest tertile of muscle CSA difference at 2-months, indicating greater symmetry in CSA between limbs, performed better than the other two tertiles at 6-months. Males performed worse in functional measures at baseline and did not recover as well as females (p= 0.02). Conclusions CT-scan measures of muscle CSA and fatty infiltration were associated with function at 2-months post-hip fracture and with improvement in function by 6 months. Observed sex differences in these associations suggest that rehabilitation strategies may need to be adapted by sex after hip fracture.

中文翻译：

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大腿肌肉成分及其与髋部骨折后功能恢复的关系随时间的推移和性别之间的关系


背景 CT 扫描测量的肌肉成分可能与髋部骨折后的恢复有关。方法 在巴尔的摩髋关节研究第 7 队列的一项辅助研究中，对老年人在髋部骨折后 2 个月和 6 个月进行了评估。 2 个月时获得肌肉 CT 扫描测量结果。在 2 个月和 6 个月时测量短期物理性能电池 (SPPB)。使用广义估计方程来模拟肌肉测量和身体功能的关联，并根据年龄、性别、体重指数和骨折后时间进行调整。结果 71 名老年人（52% 为男性，年龄 79.6 ± 7.3 岁）纳入其中。 2 个月时，与女性相比，男性骨折侧的大腿横截面积 (CSA, p<0.0001) 更大，低密度肌肉 (p=0.047) 和肌间脂肪组织 (p=0.007) 更少，而女性在 SPPB 上表现更好 (p= 0.05)。无论男女，骨折侧的肌肉测量值均与 2 个月时的功能相关。 2 个月时肌肉 CSA 差异最低三分位数的受试者（表明四肢之间 CSA 具有更大的对称性）在 6 个月时表现优于其他两个三分位数。男性在基线时的功能测量表现较差，并且恢复情况不如女性 (p = 0.02)。结论 肌肉 CSA 和脂肪浸润的 CT 扫描测量与髋部骨折后 2 个月的功能以及 6 个月时的功能改善相关。在这些关联中观察到的性别差异表明，髋部骨折后康复策略可能需要根据性别进行调整。