Challenges for optical nanothermometry in biological environments,Chemical Society Reviews

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Challenges for optical nanothermometry in biological environments
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-05-19 , DOI: 10.1039/d2cs00069e
Marta Quintanilla ₁ , Malou Henriksen-Lacey _{2,

3} , Carlos Renero-Lecuna _{2,

3} , Luis M Liz-Marzán _{2,

3,

4}

Affiliation

Temperature monitoring is useful in medical diagnosis, and essential during hyperthermia treatments to avoid undesired cytotoxic effects. Aiming to control heating doses, different temperature monitoring strategies have been developed, largely based on luminescent materials, a.k.a. nanothermometers. However, for such nanothermometers to work, both excitation and emission light beams must travel through tissue, making its optical properties a relevant aspect to be considered during the measurements. In complex tissues, heterogeneity, and real-time alterations as a result of therapeutic treatment may have an effect on light-tissue interaction, hindering accuracy in the thermal reading. In this Tutorial Review we discuss various methods in which nanothermometers can be used for temperature sensing within heterogeneous environments. We discuss recent developments in optical (nano)thermometry, focusing on the incorporation of luminescent nanoparticles into complex in vitro and in vivo models. Methods formulated to avoid thermal misreading are also discussed, considering their respective advantages and drawbacks.

中文翻译：

生物环境中光学纳米测温的挑战

温度监测在医学诊断中很有用，并且在热疗期间必不可少，以避免不希望的细胞毒性作用。为了控制加热剂量，已经开发了不同的温度监测策略，主要基于发光材料，即纳米温度计。然而，要使这种纳米温度计工作，激发和发射光束都必须穿过组织，使其光学特性成为测量过程中需要考虑的相关方面。在复杂的组织中，治疗导致的异质性和实时变化可能会对光组织相互作用产生影响，从而阻碍热读数的准确性。在本教程回顾中，我们讨论了各种方法，在这些方法中，纳米温度计可用于异质环境中的温度传感。体外和体内模型。还讨论了为避免热误读而制定的方法，考虑到它们各自的优点和缺点。

更新日期：2022-05-19

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