Gastric adenocarcinoma is major type of gastric cancer that endangers human health. AKIRIN2 has been shown to be associated with cholangiocarcinoma promoting invasion and angiogenesis. In this study, AKIRIN2 is highly expressed in Gastric adenocarcinoma through bioinformatics analysis based on Stomach adenocarcinoma samples data from The Cancer Genome Atlas. Correlation analysis showed that the high-expression of AKIRIN2 was associated with poor survival rate compared to the low-expression group. Univariate and multivariate Cox regression analyses determined the correlation between clinical characteristics and overall survival. Next, the correlation between AKIRIN2 and immune infiltration was evaluated. The distribution of 24 immune cells and their correlation with the expression of AKIRIN2 were explored using the immune cell database. In addition, three Immune cell methods were used to verify the positive correlation between immune cells and AKIRIN2. Also, Genomics of Drug Sensitivity in Cancer database was utilized to verify the correlation between AKIRIN2 expression level and the efficacy of chemotherapy and immunotherapy. The results showed that AKIRIN2 is an effective biomarker of Gastric adenocarcinoma prognosis, which can guide chemotherapy and immunotherapy and clarify the progress of Gastric adenocarcinoma promoted by immune microenvironment.

胃癌是危害人类健康的主要胃癌类型。AKIRIN2 已被证明与胆管癌促进侵袭和血管生成有关。在这项研究中，通过基于癌症基因组图谱的胃腺癌样本数据的生物信息学分析，AKIRIN2 在胃腺癌中高表达。相关性分析表明，与低表达组相比，AKIRIN2的高表达与较差的存活率相关。单变量和多变量 Cox 回归分析确定了临床特征和总生存期之间的相关性。接下来，评估了 AKIRIN2 与免疫浸润之间的相关性。使用免疫细胞数据库探讨了 24 个免疫细胞的分布及其与 AKIRIN2 表达的相关性。此外，三种免疫细胞方法用于验证免疫细胞与AKIRIN2之间的正相关关系。此外，还利用癌症数据库中药物敏感性基因组学来验证 AKIRIN2 表达水平与化学疗法和免疫疗法疗效之间的相关性。结果表明，AKIRIN2是胃癌预后的有效生物标志物，可指导化疗和免疫治疗，阐明免疫微环境促进的胃癌进展。