Recent advances in self-immolative linkers and their applications in polymeric reporting systems,Polymer Chemistry

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Recent advances in self-immolative linkers and their applications in polymeric reporting systems
Polymer Chemistry ( IF 4.1 ) Pub Date : 2022-05-18 , DOI: 10.1039/d2py00414c
Alexander G. Gavriel ₁ , Mark R. Sambrook ₂ , Andrew T. Russell ₁ , Wayne Hayes ₁

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Interest in self-immolative chemistry has grown over the past decade with more research groups harnessing the versatility to control the release of a compound from a larger chemical entity, given a specific stimulus. Originally conceived in 1981 to overcome electronic or steric features which may prohibit cleavage of a prodrug linkage; today's self-immolative linkers are widely used, inter alia, within medicinal chemistry, analytical chemistry, and material science. The incorporation of these linkers can be found in small molecules, dendritic and polymeric systems where a controlled release profile is required. This control can be of a binary character, release or not release, or a more nuanced issue of rate of release. In this article, we build upon our previous review in 2011 discussing key literature within the self-immolative field and, in particular, a selection of more recent examples that highlight how this field has matured in the past decade, with relevant earlier literature to provide context.

中文翻译：

自牺牲接头的最新进展及其在聚合物报告系统中的应用

在过去的十年中，人们对自焚化学的兴趣与日俱增，越来越多的研究小组利用多功能性来控制化合物从更大的化学实体中的释放，给定特定的刺激。最初构想于 1981 年，以克服可能阻止前药连接断裂的电子或空间特征；今天的自我牺牲连接器被广泛使用，尤其是，在药物化学、分析化学和材料科学中。这些接头的掺入可以在需要控制释放曲线的小分子、树枝状和聚合物系统中找到。这种控制可以是二进制字符，释放或不释放，或者更细微的释放速率问题。在这篇文章中，我们在 2011 年回顾自焚领域的关键文献的基础上进行了讨论，特别是选择了一些最近的例子，这些例子突出了这个领域在过去十年中是如何成熟的，并提供了相关的早期文献语境。

更新日期：2022-05-18

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