Metal-free visible-light-induced multi-component reactions of α-diazoesters leading to S-alkyl dithiocarbamates,Organic Chemistry Frontiers

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Metal-free visible-light-induced multi-component reactions of α-diazoesters leading to S-alkyl dithiocarbamates
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-05-18 , DOI: 10.1039/d2qo00311b
Yufen Lv _{1,

2} , Ruisheng Liu ₁ , Hongyu Ding ₁ , Wei Wei _{1,

3} , Xiaohui Zhao ₃ , Lin He ₂

Affiliation

A metal-free and visible-light-promoted method has been developed for the synthesis of S-alkyl dithiocarbamates through multicomponent reactions of α-diazoesters, amines and CS₂. The present transformation could be conveniently performed at room temperature in air by simply using DBU as the additive, in which nitrogen was generated as the only side-product. Interestingly, a series of structurally diverse four-component coupling products with the incorporation of the ring-opening of THF could be rapidly and efficiently obtained when the reaction of α-aryldiazoesters, amines and CS₂ was performed in THF.

中文翻译：

α-重氮酯的无金属可见光诱导多组分反应生成 S-烷基二硫代氨基甲酸酯

已经开发了一种无金属和可见光促进的方法，用于通过 α-重氮酯、胺和 CS ₂的多组分反应合成S-烷基二硫代氨基甲酸酯。通过简单地使用 DBU 作为添加剂，可以在室温下在空气中方便地进行本转化，其中氮气作为唯一的副产物产生。_{有趣的是，在 THF 中进行 α-芳基重氮酯、胺和 CS 2}的反应时，可以快速有效地获得一系列结构多样的四组分偶联产物，并结合 THF 的开环。

更新日期：2022-05-18

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