The safety of ethanol in operations and its effects on human health are gradually being questioned. Under this premise, we attempted to use the natural surfactant tea saponin, which originates from the processing residues of camellia oil, as the additive of the extraction solvent and to extract eleutheroside B and eleutheroside E in the roots and rhizomes of E. senticosus by ultrasonic mediation. After a single-factor experiment, extraction kinetics at different powers and reaction temperatures, and Box–Behnken design optimization, the optimal conditions obtained were 0.3% tea saponin solution as the extraction solvent, 20 mL/g liquid–solid ratio, 250 W ultrasonic irradiation power (43.4 mW/g ultrasonic power density) and 40 min ultrasonic irradiation time. Under optimal conditions, satisfactory yields of eleutheroside B (1.06 ± 0.04 mg/g) and eleutheroside E (2.65 ± 0.12 mg/g) were obtained with semi pilot scale ultrasonic extraction equipment. The experiments showed that compared with the traditional thermal extraction process, the extraction time is significantly reduced at lower operating temperatures.

乙醇在操作中的安全性及其对人体健康的影响逐渐受到质疑。在此前提下，我们尝试使用来源于山茶油加工残渣的天然表面活性剂茶皂素作为提取溶剂的添加剂，提取了刺五加根和根茎中的刺五加苷B和刺五加苷E。通过超声介导。经过单因素实验、不同功率和反应温度下的提取动力学和Box-Behnken设计优化，得到的最佳条件为0.3%茶皂素溶液作为提取溶剂、20 mL/g液固比、250 W超声波辐照功率（43.4 mW/g 超声波功率密度）和 40 分钟的超声波辐照时间。在最佳条件下，采用半中试规模的超声提取设备，获得了令人满意的刺五加苷 B (1.06 ± 0.04 mg/g) 和刺五加苷 E (2.65 ± 0.12 mg/g) 的收率。实验表明，与传统的热萃取工艺相比，在较低的操作温度下萃取时间显着缩短。