Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer,Advanced Materials

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Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer
Advanced Materials ( IF 27.4 ) Pub Date : 2022-05-18 , DOI: 10.1002/adma.202201651
Jia-Qi Zhu _{1,

2} , Han Wu _{1,

3} , Zhen-Li Li _{1,

3} , Xin-Fei Xu ₃ , Hao Xing ₃ , Ming-Da Wang ₃ , Hang-Dong Jia ₁ , Lei Liang ₁ , Chao Li ₃ , Li-Yang Sun ₁ , Yu-Guang Wang ₂ , Feng Shen ₃ , Dong-Sheng Huang _{1,

4} , Tian Yang _{1,

3}

Affiliation

Globally, liver cancer, which is one of the major cancers worldwide, has attracted the growing attention of technological researchers for its high mortality and limited treatment options. Hydrogels are soft 3D network materials containing a large number of hydrophilic monomers. By adding moieties such as nitrobenzyl groups to the network structure of a cross-linked nanocomposite hydrogel, the click reaction improves drug-release efficiency in vivo, which improves the survival rate and prolongs the survival time of liver cancer patients. The application of a nanocomposite hydrogel drug delivery system can not only enrich the drug concentration at the tumor site for a long time but also effectively prevents the distant metastasis of residual tumor cells. At present, a large number of researches have been working toward the construction of responsive nanocomposite hydrogel drug delivery systems, but there are few comprehensive articles to systematically summarize these discoveries. Here, this systematic review summarizes the synthesis methods and related applications of nanocomposite responsive hydrogels with actions to external or internal physiological stimuli. With different physical or chemical stimuli, the structural unit rearrangement and the controlled release of drugs can be used for responsive drug delivery in different states.

中文翻译：

基于触发点击反应的响应性水凝胶用于肝癌

在全球范围内，肝癌作为全球主要癌症之一，以其高死亡率和有限的治疗选择越来越受到技术研究人员的关注。水凝胶是含有大量亲水性单体的柔软 3D 网络材料。通过在交联纳米复合水凝胶的网络结构中加入硝基苄基等基团，点击反应提高了体内药物释放效率，从而提高了肝癌患者的存活率，延长了存活时间。纳米复合水凝胶给药系统的应用不仅可以长期丰富肿瘤部位的药物浓度，还可以有效防止残留肿瘤细胞的远处转移。现在，大量的研究一直致力于构建响应性纳米复合水凝胶药物递送系统，但很少有综合性的文章系统地总结这些发现。在这里，本系统综述总结了对外部或内部生理刺激起作用的纳米复合响应性水凝胶的合成方法和相关应用。在不同的物理或化学刺激下，药物的结构单元重排和控释可用于不同状态的响应性药物递送。本系统综述总结了对外部或内部生理刺激具有作用的纳米复合响应性水凝胶的合成方法和相关应用。在不同的物理或化学刺激下，药物的结构单元重排和控释可用于不同状态的响应性药物递送。本系统综述总结了对外部或内部生理刺激具有作用的纳米复合响应性水凝胶的合成方法和相关应用。在不同的物理或化学刺激下，药物的结构单元重排和控释可用于不同状态的响应性药物递送。

更新日期：2022-05-18

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