The presented article is relevant, as the main goals of schizophrenia treatment are to achieve a response to psychopharmacotherapy, reduction and stabilization of psychopathological symptoms, qualitative remission, which in general implies the creation of a stable quality of life for the patient. The purpose of the study was to evaluate the population features of the frequency distribution of alleles and genotypes of polymorphic genetic variants of according to genome-wide association studies analysis of pharmacokinetics-associated antipsychotic medications, in an ethnically homogeneous Kazakh population. The research material was deoxyribonucleic acid (DNA) isolated from the peripheral blood of 1,800 conditionally healthy persons of Kazakh nationality. DNA isolation was carried out by the magnetic polyvinyl alcohol magnetic particle separation method. The analysis of the frequency distribution of the studied genotypes in the Kazakh population showed their compliance with the Hardy-Weinberg equilibrium for all studied polymorphisms (p > .05). The obtained results showed that CYP2C19 (rs4244285, rs4986893) polymorphisms occurs in Kazakhs significantly more often than European and a number of Asian populations, which significantly affects the decrease in effectiveness and increases the risk of side complications during therapy with antipsychotic medications in the Kazakh population.

中文翻译：

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哈萨克族人群抗精神病药物药代动力学多态性遗传标记的等位基因和基因型频率分布的人群特征。


本文提出的文章是相关的，因为精神分裂症治疗的主要目标是实现对精神药物治疗的反应、精神病理症状的减少和稳定、定性缓解，这通常意味着为患者创造稳定的生活质量。该研究的目的是根据全基因组关联研究对民族同质的哈萨克人群中药代动力学相关抗精神病药物的分析，评估等位基因频率分布和多态性遗传变异基因型的人群特征。研究材料是从1800名哈萨克族健康人的外周血中分离出的脱氧核糖核酸（DNA）。采用磁性聚乙烯醇磁珠分离法进行DNA分离。对哈萨克人群中所研究基因型的频率分布的分析表明，所有研究的多态性均符合 Hardy-Weinberg 平衡 (p > .05)。获得的结果表明，CYP2C19（rs4244285、rs4986893）多态性在哈萨克族人群中的发生率显着高于欧洲和一些亚洲人群，这显着影响了哈萨克族人群抗精神病药物治疗过程中有效性的下降并增加了副作用的风险。