The paper presents the synthesis of hydrogels via free-radical polymerization, based on Chitosan (CS) grafted with Acrylic acid (AA), using a two-step procedure. Free-radical polymerization has given strong hydrogels with compact structure, dominant elastic behavior, and long linear viscoelastic region. The results of rheological studies have shown that obtained hydrogels have significantly improved mechanical properties in comparison to chitosan hydrogels obtained by other sustainable methods. A step forward in the investigation of the potential application of chitosan hydrogels in wound dressing systems has been made by preparation of the bilayer design by embedding a layer of active compound-loaded alginate beads into the contact surface between two conjoined units of CS/AA hydrogels. Wild garlic (Allium ursinum L.) dried extract was used as an active compound because of its antimicrobial activity and green properties. This system has demonstrated pH-dependent release of extract and higher shear elastic modulus values than ordinary disc gels. A conducted study has given preliminary results for the possible application of bilayer chitosan-based hydrogels in wound dressing systems and represents the first step towards extrapolating the proposed design across other application fields.

本文介绍了通过自由基聚合法合成水凝胶，该方法基于用丙烯酸 (AA) 接枝的壳聚糖 (CS)，采用两步法。自由基聚合使强水凝胶具有紧凑的结构、主要的弹性行为和长的线性粘弹性区域。流变学研究结果表明，与通过其他可持续方法获得的壳聚糖水凝胶相比，获得的水凝胶具有显着改善的机械性能。在研究壳聚糖水凝胶在伤口敷料系统中的潜在应用方面向前迈进了一步，通过将一层负载活性化合物的藻酸盐珠嵌入到两个 CS/AA 水凝胶联合单元之间的接触表面中，制备双层设计. 野蒜 ( Allium ursinum L.) 干燥提取物因其抗菌活性和绿色特性而被用作活性化合物。该系统已证明提取物的 pH 依赖性释放和比普通圆盘凝胶更高的剪切弹性模量值。一项已进行的研究为双层壳聚糖基水凝胶在伤口敷料系统中的可能应用提供了初步结果，并代表了将提议的设计外推到其他应用领域的第一步。