Aims To investigate the association between the choriocapillaris flow deficit percentage (CC FD%) and the 1-year incidence of referable diabetic retinopathy (RDR) in participants with type 2 diabetes mellitus (DM). Methods This prospective cohort study included participants with type 2 DM. The DR status was graded based on the ETDRS-7 photography. The CC FD% in the central 1 mm area, inner circle (1.5 mm to 2.5 mm), outer circle (2.5 mm to 5.0 mm) and the entire area in the macular region were measured using swept-source optical coherence tomography angiography (SS-OCTA). Logistic regression analysis was used to examine the association between baseline CC FD% and 1-year incident RDR. Results A total of 1222 patients (1222 eyes, mean age: 65.1±7.4 years) with complete baseline and 1-year follow-up data were included. Each 1% increase in baseline CC FD% was significantly associated with a 1.69 times (relative risk 2.69; 95% CI 1.53 to 4.71; p=0.001) higher odds for development of RDR after 1-year follow-up, after adjusting for other confounding factors. Conclusions A greater baseline CC FD% detected by SS-OCTA reliably predicted higher risks of RDR in participants with type 2 DM. Thus, CC FD% may act as a novel biomarker for predicting the onset and progression of DR. Data are available upon reasonable request.

中文翻译：

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脉络膜毛细血管血流不足和糖尿病性视网膜病变的风险：一项纵向 SS-OCTA 研究

目的 调查 2 型糖尿病 (DM) 参与者的脉络膜毛细血管血流缺陷百分比 (CC FD%) 与 1 年糖尿病视网膜病变 (RDR) 发生率之间的关联。方法 这项前瞻性队列研究纳入了 2 型糖尿病参与者。DR 状态根据 ETDRS-7 照片进行分级。使用扫频光学相干断层扫描血管造影（SS）测量中央1mm区域、内圈（1.5mm至2.5mm）、外圈（2.5mm至5.0mm）以及黄斑区整个区域的CC FD% -OCTA）。Logistic 回归分析用于检查基线 CC FD% 与 1 年事件 RDR 之间的关联。结果共有1222例患者（1222只眼，平均年龄：65.1±7.4岁）具有完整的基线和1年随访数据。基线 CC FD% 每增加 1%，在调整其他因素后，1 年随访后发生 RDR 的几率就会增加 1.69 倍（相对风险 2.69；95% CI 1.53 至 4.71；p=0.001）。混杂因素。结论 SS-OCTA 检测到的基线 CC FD% 较高，可以可靠地预测 2 型糖尿病参与者发生 RDR 的风险较高。因此，CC FD% 可能作为预测 DR 发病和进展的新型生物标志物。数据可根据合理要求提供。