Introduction Metabolic Syndrome (MetS) represents a common dysmetabolic state in children with obesity. Although data in youth show a role of gut hormones (GH) in the risk of developing MetS, no data are available during the prepubertal age, especially across clusters of MetS. Methods We characterized components of MetS and changes in GH concentrations in 90 prepubertal children with obesity compared to 30 healthy age-and gender matched peers. Children with obesity were divided into three groups according to the number of the components of MetS (group 1: 30 obese without components of MetS; group 2: 30 obese with 1 component of MetS; group 3: 30 obese with 2 or more components of MetS). Anthropometric parameters, blood pressure (BP), fasting insulin and glycaemia, lipid profile, transaminases and GH concentration were determined. Differences across the groups were evaluated by Kruskal-Wallis test and post-hoc analysis by Mann-Whithney test. Results Fasting glycaemia and insulin, HOMA-IR, Triglycerides, BP progressively increased and High Density Lipoprotein (HDL) progressively decreased across the groups of children with obesity compared to controls, showing worse values in group 3. GLP-1 and Ghrelin values progressively decreased and Obestatin progressively increased. The more components of the Mets were presents, the further GH concentrations deviated from standard values. Discussion and Conclusion Components of MetS and GH concentrations are impaired in prepubertal children with obesity compared to controls. The close association between progressive alterations in GH levels and increasing number of components of the MetS might indicate a role of these hormones in the determination of metabolic risk.


中文翻译：

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青春期前肥胖儿童代谢综合征群的肠道激素分泌

简介 代谢综合征 (MetS) 是肥胖儿童常见的代谢异常状态。尽管青少年的数据显示肠道激素 (GH) 在发生 MetS 的风险中的作用，但在青春期前阶段没有可用的数据，尤其是跨 MetS 集群。方法 我们对 90 名青春期前肥胖儿童与 30 名年龄和性别匹配的健康同龄儿童的 MetS 成分和 GH 浓度变化进行了表征。肥胖儿童根据 MetS 成分的数量分为三组（第 1 组：30 名肥胖者没有 MetS 成分；第 2 组：30 名肥胖者有 1 种 MetS 成分；第 3 组：30 名肥胖者有 2 种或更多大都会）。测定人体测量参数、血压 (BP)、空腹胰岛素和血糖、血脂、转氨酶和 GH 浓度。通过 Kruskal-Wallis 检验和 Mann-Whithney 检验的事后分析评估组间的差异。结果 与对照组相比，肥胖儿童组的空腹血糖和胰岛素、HOMA-IR、甘油三酯、BP 逐渐升高，高密度脂蛋白 (HDL) 逐渐降低，显示第 3 组的值更差。GLP-1 和 Ghrelin 值逐渐降低和 Obestatin 逐渐增加。存在的 Mets 成分越多，GH 浓度越偏离标准值。讨论和结论 与对照组相比，青春期前肥胖儿童的 MetS 和 GH 浓度成分受损。