With the modernization and internationalization of traditional Chinese medicine (TCM), the requirement for quality control has increased. The quality marker (Q-marker) is an important standard in this field and has been implemented with remarkable success in recent years. However, the establishment of Q-markers remains fragmented and the process lacks systematicity, resulting in inconsistent quality control and insufficient correlation with clinical efficacy and safety of TCM. This review introduces four multimodal integrated approaches that contribute to the discovery of more comprehensive and accurate Q-markers, thus aiding in the establishment of new quality control patterns based on the characteristics and principles of TCM. These include the whole-process quality control strategy, chemical-activity-based screening method, efficacy, safety, and consistent combination strategy, and TCM theory-guided approach. Furthermore, methodologies and representative examples of these strategies are described, and important future directions and questions in this field are also proposed.

随着中医药（TCM）的现代化和国际化，对质量控制的要求越来越高。质量标记（Q-marker）是该领域的一个重要标准，近年来已取得显著成功。然而，Q-markers的建立仍然碎片化，过程缺乏系统性，导致质量控制不一致，与中药临床疗效和安全性相关性不足。本综述介绍了四种多模式综合方法，有助于发现更全面和准确的 Q 标记，从而有助于建立基于中医特征和原则的新质量控制模式。其中包括全过程质量控制策略、基于化学活性的筛选方法、有效性、安全性、和一致的组合策略，以及中医理论指导的方法。此外，还描述了这些策略的方法和代表性示例，并提出了该领域未来的重要方向和问题。