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Signal length not strength guides T cell fate
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2022-05-16 , DOI: 10.1038/s41577-022-00736-x
Kirsty Minton 1
Affiliation  

FlipFlop mice, in which the coreceptor proteins encoded by the Cd4 and Cd8 loci are reversed, shed light on the importance of T cell receptor signal length versus signal strength in determining helper versus cytotoxic T cell lineage fates.

中文翻译:

信号长度而非强度指导 T 细胞命运

FlipFlop 小鼠(其中由 Cd4 和 Cd8 基因座编码的共受体蛋白被逆转)揭示了 T 细胞受体信号长度与信号强度在确定辅助性与细胞毒性 T 细胞谱系命运中的重要性。
更新日期:2022-05-16
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