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High-resolution accurate mass approach to characterization of SCO-267 metabolites using liquid chromatography hybrid quadrupole Orbitrap mass spectrometry
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2022-05-13 , DOI: 10.1002/rcm.9325
Ying Zhu 1 , Ting Wang 2 , Na Zhao 2 , Wenya Jiang 2
Affiliation  

SCO-267 is a potent full agonist of G-protein-coupled receptor 40. As a promising therapeutic agent for type 2 diabetes mellitus, it is necessary to elucidate its metabolite profiles during the stage of drug development for safety considerations.

中文翻译:

使用液相色谱混合四极杆 Orbitrap 质谱法表征 SCO-267 代谢物的高分辨率精确质量方法

SCO-267 是一种有效的 G 蛋白偶联受体 40 完全激动剂。作为一种有前途的 2 型糖尿病治疗剂,出于安全考虑,有必要在药物开发阶段阐明其代谢物谱。
更新日期:2022-05-13
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