The localized surface plasmon resonance (LSPR) excitations are critical towards achieving sizable spectral enhancements of the Raman scattered light. Herein, the synthesis of palladium-based highly reduced graphene oxide (Pd-HRG) with LSPR properties as an effective surface-enhanced Raman scattering (SERS) substrate and its utility in the highly sensitive detection of procaine are reported. The concentration detection of procaine samples was optimized by applying a set of pre-concentration parameters. The Pd-HRG nanocomposite showed a remarkable LSPR response with a Raman enhancement factor of 8.7 × 10². The Pd-HRG is employed to modify fluorine doped tin oxide electrode (Pd-HRG/FTO), resulted with an enhancement factor of 7.5 × 10⁴ corresponding to the EC-SERS technique. The electronic and surface properties of synthesized Pd-HRG and functionalized FTO electrode were evaluated using Raman, infrared, EIS, XRD, FESEM and EDX techniques. Quantum chemical calculations were carried out to elaborate on the nature of interaction of procaine molecules with a nanostructured surface model. Pd-HRG, with an efficient and cost-effective fabrication, can be considered as a promising EC-SERS substrate for the detection of organic therapeutic drugs.

局部表面等离子体共振 (LSPR) 激发对于实现拉曼散射光的可观光谱增强至关重要。本文报道了具有 LSPR 特性的钯基高度还原氧化石墨烯 (Pd-HRG) 作为有效的表面增强拉曼散射 (SERS) 基板的合成及其在普鲁卡因高灵敏度检测中的应用。通过应用一组预浓缩参数优化普鲁卡因样品的浓度检测。Pd-HRG 纳米复合材料显示出显着的 LSPR 响应，拉曼增强因子为 8.7 × 10 ²。Pd-HRG 用于修饰氟掺杂氧化锡电极 (Pd-HRG/FTO)，其增强因子为 7.5 × 10 ⁴对应于 EC-SERS 技术。使用拉曼、红外、EIS、XRD、FESEM 和 EDX 技术评估合成的 Pd-HRG 和功能化 FTO 电极的电子和表面性质。进行了量子化学计算以详细说明普鲁卡因分子与纳米结构表面模型相互作用的性质。Pd-HRG 具有高效且具有成本效益的制造方法，可被视为用于检测有机治疗药物的有前途的 EC-SERS 基板。