Diagnosis of diabetic cataract (DC) in the early stage is of great significance for drug intervention and surgery circumvention for DC patients. However, the lack of reliable imaging tools greatly limits the diagnosis of early DC. In this context, a fluorescent probe BBPy for hypochlorous acid (HOCl) is presented based on the oxidation of phenothiazine. The probe displays apparent emission enhancement at 562 nm toward HOCl with high selectivity, superb sensitivity (detection limit: 12.6 nM), and rapid response (within seconds). Using the probe, the HOCl generation in diabetic human lens epithelial cells was monitored, as well as the HOCl down-regulation during antioxidant treatment. Therefore, it is proposed that HOCl can be a promising biomarker for DC and fluorescence imaging technique can be regarded as a candidate tool for DC diagnosis.

糖尿病白内障（DC）的早期诊断对于DC患者的药物干预和手术规避具有重要意义。然而，缺乏可靠的成像工具极大地限制了早期 DC 的诊断。在这种情况下，荧光探针BBPy次氯酸 (HOCl) 是基于吩噻嗪的氧化提出的。该探针在 562 nm 处对 HOCl 显示出明显的发射增强，具有高选择性、卓越的灵敏度（检测限：12.6 nM）和快速响应（几秒钟内）。使用该探针，监测了糖尿病人晶状体上皮细胞中的次氯酸生成，以及抗氧化治疗期间次氯酸的下调。因此，建议HOCl可以作为DC的有前途的生物标志物，荧光成像技术可以作为DC诊断的候选工具。