Photo-Catalyzed Redox-Neutral 1,2-Dialkylation of Alkenes,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Photo-Catalyzed Redox-Neutral 1,2-Dialkylation of Alkenes
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-05-13 , DOI: 10.1002/adsc.202200310
Wen-Hui Sun ₁ , Jian-Yu Zou ₁ , xiao-jing xu ₂ , Jin-Lin Wang ₁ , mei-ling liu ₂ , Xue-yuan Liu ₁

Affiliation

Difunctionalization of alkenes enables construction of complex compounds in one pot. In this report, we presented an intermolecular, redox-neutral three-component dicarbofunctionalization of activated alkenes under mild reaction conditions. The mechanistic studies indicated tertiary alkyl radicals from oxalate salts were first added to alkenes in Giese-type fashion, followed by nucleophilic addition with aldehydes to produce the desired 1,2-dialkylation products. The catalyst system does not require any additives, with good functional group compatibility, regioselectivity, and constructs two tertiary carbon centers simultaneously.

中文翻译：

烯烃的光催化氧化还原中性 1,2-二烷基化

烯烃的双官能化能够在一锅中构建复杂的化合物。在本报告中，我们提出了在温和反应条件下活化烯烃的分子间、氧化还原中性三组分二碳官能化。机理研究表明，草酸盐的叔烷基自由基首先以 Giese 型方式添加到烯烃中，然后与醛进行亲核加成以产生所需的 1,2-二烷基化产物。该催化剂体系不需要任何添加剂，具有良好的官能团相容性和区域选择性，同时构建了两个叔碳中心。

更新日期：2022-05-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11