Background: We investigated whether serum levels of immunoglobin (Ig) E and Nε-carboxymethyl-lysine (CML) are related to in-stent restenosis (ISR) in patients with stable coronary artery disease and type 2 diabetes mellitus (T2DM). Methods: Serum levels of IgE and CML were measured in 196 ISR patients and 220 non-ISR patients with stable angina and T2DM who received angiographic follow-up 12 months after percutaneous coronary intervention (PCI) with third-generation drug-eluting stent (DES) implantation for de novo lesions. Multivariate logistic regression analysis was performed to assess the association between IgE or CML and ISR. Results: Both IgE and CML levels were higher in patients with ISR compared with non-ISR patients (IgE: 187.10 (63.75–489.65) vs. 80.25 (30.65–202.50), p < 0.001; CML: 203.26 (164.50–266.84) vs. 174.26 (130.85–215.56), p < 0.001). The rate of ISR increased stepwise with increasing tertiles of IgE and CML levels (p for all trends < 0.001), and IgE correlated significantly with CML. After adjusting for potential confounders, IgE and CML levels remained independently associated with ISR. Moreover, IgE and CML levels improved the predictive capability of traditional risk factors for ISR, and there existed an interaction between IgE and CML in relation to ISR (p for interaction < 0.01). Conclusion: Elevated circulating IgE and CML levels confer an increased risk for ISR after DES-based PCI in type 2 diabetic patients with stable coronary artery disease.

中文翻译：

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循环 IgE 和 CML 水平与稳定型冠状动脉疾病 2 型糖尿病患者支架内再狭窄的关联

背景：我们调查了免疫球蛋白 (Ig) E 和 Nε-羧甲基赖氨酸 (CML) 的血清水平是否与稳定性冠状动脉疾病和 2 型糖尿病 (T2DM) 患者的支架内再狭窄 (ISR) 相关。方法：测量 196 例 ISR 患者和 220 例非 ISR 稳定型心绞痛合并 T2DM 患者的血清 IgE 和 CML 水平，这些患者在使用第三代药物洗脱支架（DES）经皮冠状动脉介入治疗（PCI）后 12 个月接受血管造影随访。 ) 植入新病变。进行多变量逻辑回归分析以评估 IgE 或 CML 与 ISR 之间的关联。结果：ISR 患者的 IgE 和 CML 水平均高于非 ISR 患者（IgE：187.10（63.75-489.65）对 80.25（30.65-202.50），p< 0.001；CML：203.26 (164.50–266.84) 对比 174.26 (130.85–215.56)，p < 0.001。随着 IgE 和 CML 水平的三分位数增加，ISR 率逐步增加（所有趋势的p < 0.001），并且 IgE 与 CML 显着相关。调整潜在混杂因素后，IgE 和 CML 水平仍然与 ISR 独立相关。此外，IgE 和 CML 水平提高了传统风险因素对 ISR 的预测能力，并且 IgE 和 CML 之间存在与 ISR 相关的交互作用（交互作用的p < 0.01）。结论：升高的循环 IgE 和 CML 水平会增加 2 型糖尿病合并稳定性冠状动脉疾病患者在基于 DES 的 PCI 后发生 ISR 的风险。