Access to 5-Substituted 3-Aminofuran/Thiophene-2-Carboxylates from Bifunctional Alkynenitriles,Advanced Synthesis & Catalysis

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Access to 5-Substituted 3-Aminofuran/Thiophene-2-Carboxylates from Bifunctional Alkynenitriles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-05-12 , DOI: 10.1002/adsc.202200305
Chandresh Kumari ₁ , Avijit Goswami ₂

Affiliation

An atom-economical approach for the synthesis of 3-aminofurans/thiophenes via a conjugate addition of alcohols and thiols with electron withdrawing groups (EWGs) at α positions on alkynenitriles followed by a modified Thorpe-Ziegler cyclization have been reported. This operationally simple protocol offers a rapid access to a library of 3-aminofurans/thiophenes in moderate to good yields.

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