Clinical features and burden of osteoporotic fractures among the elderly in the USA from 2016 to 2018,Archives of Osteoporosis

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Clinical features and burden of osteoporotic fractures among the elderly in the USA from 2016 to 2018
Archives of Osteoporosis ( IF 3.1 ) Pub Date : 2022-05-12 , DOI: 10.1007/s11657-022-01113-w
Yongfu Lou _{1,

2} , Wei Wang _{1,

2} , Chaoyu Wang _{1,

2} , Runhan Fu ₂ , Shenghui Shang _{1,

2} , Yi Kang ₁ , Chi Zhang ₂ , Huan Jian ₁ , Yigang Lv ₁ , Mengfan Hou ₁ , Lingxiao Chen _{2,

3} , Hengxing Zhou _{1,

2} , Shiqing Feng _{1,

2}

Affiliation

Summary

This study provides a national estimate of the incidence of hospitalizations and assesses the clinical features and outcomes during inpatient admission due to osteoporotic fractures diagnosed by ICD-10-CM/PCS among the elderly in the USA, using the US Nationwide Inpatient Sample, 2016–2018.

Purpose

To provide a national estimate of the incidence of hospitalizations and assess the clinical features and outcomes during inpatient admission due to osteoporotic fractures (OFs) among the elderly in the USA.

Methods

The study included all inpatients aged 65 years and older who participated in the US Nationwide Inpatient Sample (NIS). We conducted a retrospective analysis of hospitalizations with OFs diagnosed by the International Classification of Diseases, Tenth Revision, Clinical Modification/Procedure Coding System (ICD-10-CM/PCS), using the US NIS, 2016–2018. Trends in epidemiological characteristics and outcomes were calculated by annual percentage change (APC).

Results

From 2016 to 2018, there were an estimated 0.16 million hospitalizations for OFs, and the estimated annual incidence rate changed from 995 cases per 1 million persons in 2016 to 1114 cases per 1 million persons in 2018 (APC, 5.8% [95% CI, 0.0 to 12.0]; P > 0.05). Over two-thirds of the patients (68.2%) were age-related osteoporosis with current pathological fracture, and OFs were more likely to occur in vertebra (51.7%) and femur (34.7%). During the hospitalization, the average length of stay (LOS) was 5.83 days, the average cost reached $60,901.04, and the overall mortality was 2.3%. All outcomes including LOS, average cost and mortality did not change significantly in 2016–2018 (all P values for trend were over 0.05).

Conclusion

Between 2016 and 2018, the incidence rate of OFs remained relatively stable, but the total number of cases was huge. OFs was predominantly age-related, mostly in vertebrae and femurs, with relatively stable cost and mortality during hospitalization.

中文翻译：

2016-2018年美国老年人骨质疏松性骨折临床特征及负担

概括

本研究使用美国全国住院患者样本，2016– 2018.

目的

旨在提供美国老年人住院率的全国估计值，并评估因骨质疏松性骨折 (OFs) 而住院的美国老年人的临床特征和结果。

方法

该研究包括参与美国全国住院患者样本 (NIS) 的所有 65 岁及以上住院患者。我们使用美国 NIS，2016-2018 年对国际疾病分类第十版临床修改/程序编码系统 (ICD-10-CM/PCS) 诊断的 OF 住院进行了回顾性分析。流行病学特征和结果的趋势是通过年度百分比变化 (APC) 计算的。

结果

从 2016 年到 2018 年，估计有 16 万人因 OF 住院，估计年发病率从 2016 年的每百万人 995 例变为 2018 年的每百万人 1114 例（APC，5.8% [95% CI， 0.0 至 12.0]；P > 0.05）。超过三分之二的患者 (68.2%) 是与年龄相关的骨质疏松症伴有病理性骨折，OFs 更容易发生在椎骨 (51.7%) 和股骨 (34.7%)。住院期间，平均住院时间（LOS）为5.83天，平均费用达到60,901.04美元，总死亡率为2.3%。包括 LOS、平均成本和死亡率在内的所有结果在 2016-2018 年都没有显着变化（趋势的所有P值均超过 0.05）。