Background

The aim of this meta-analysis was to evaluate the efficacy and safety of peri-articular injection of tranexamic acid (TXA) during total knee arthroplasty (TKA) from clinical controlled trials.

Method

Eligible scientific articles published prior to October 2021 were retrieved from the PubMed, Springer, ScienceDirect and Cochrane Library databases. The statistical analysis was performed with RevMan 5.1.

Result

2 RCTs and 3 non-RCTs met the inclusion criteria. Meta-analysis showed significant differences in terms of hemoglobin reduction (MD = −1.04, 95% CI: −1.33 to −.76, P < .00001), total blood loss (MD = −342.80.70, 95% CI: −437.52 to −248.08, P < .00001), drainage volume (MD = −297.24, 95% CI: −497.26 to −97.23, P = .004) and blood transfusion rate (OR = .30, 95% CI: .14 to .62, P = .001) were found in the control group. No postoperative infection and deep venous thrombosis were found between 2 groups.

Conclusion

Peri-articular injection of TXA can effectively decrease perioperative blood loss and blood transfusion rate without increasing the incidence of postoperative complications during TKA.

中文翻译：

---

关节周围注射氨甲环酸可减少全膝关节置换术期间的失血和输血需求：一项荟萃分析

背景

这项荟萃分析的目的是评估临床对照试验在全膝关节置换术 (TKA) 期间关节周围注射氨甲环酸 (TXA) 的疗效和安全性。

方法

从 PubMed、Springer、ScienceDirect 和 Cochrane 图书馆数据库中检索到 2021 年 10 月之前发表的符合条件的科学文章。使用 RevMan 5.1 进行统计分析。

结果

2 项 RCT 和 3 项非 RCT 符合纳入标准。Meta 分析显示在血红蛋白减少（MD = -1.04, 95% CI: -1.33 to -.76, P < .00001）、总失血量（MD = -342.80.70, 95% CI: - 437.52 至 -248.08, P < .00001)，引流量 (MD = -297.24, 95% CI: -497.26 至 -97.23, P = .004) 和输血率 (OR = .30, 95% CI: .14到 .62，P = .001）在对照组中发现。2组均未发现术后感染及深静脉血栓形成。

结论

关节周围注射TXA可有效减少围手术期失血量和输血率，且不增加TKA术后并发症的发生率。