Chronic wounds, especially those caused by drug-resistant bacteria, remain mostly intractable to existing treatments. Photothermal therapy, apart from the additional inflammation it may cause, exhibits potent ability to efficiently destroy drug-resistant bacteria. A system capable of thermal therapy together with active regulation of the repairing process could be a potentially effective treatment for these wounds. Here we developed a highly integrated hydrogel made of curcumin loaded copper-tetrakis(4-carboxyphenyl)porphyrin metal–organic framework and poly (ethylene glycol)-poly(ε-caprolactone-co-lactide) hybrid by in situ ring-opening polymerization. It combines photothermal effect, immune modulatory, hemostasis and temperature-sensitive sol–gel transition capacity. This multifunctional polymer-metal–organic framework (polyMOF) hydrogel dressing showed the ability to completely heal drug-resistant bacteria infected wounds within 14 days and could be an effective and biocompatible material for chemo-photothermal therapy against chronic wounds. Moreover, our strategy to prepare the polyMOF hybrid may provide a universal approach for the development of multifunctional gels with great significance in clinical application.

慢性伤口，尤其是由耐药细菌引起的伤口，对于现有的治疗方法来说仍然很棘手。光热疗法除了可能引起的额外炎症外，还表现出有效破坏耐药细菌的强大能力。能够进行热疗以及对修复过程进行主动调节的系统可能是这些伤口的潜在有效治疗方法。在这里，我们开发了一种高度集成的水凝胶，由负载姜黄素的铜-四（4-羧基苯基）卟啉金属-有机骨架和聚（乙二醇）-聚（ε-己内酯-共-丙交酯）杂化物通过原位开环聚合制成。它结合了光热效应、免疫调节、止血和温度敏感的溶胶-凝胶转变能力。这种多功能聚合物-金属-有机框架 (polyMOF) 水凝胶敷料显示出能够在 14 天内完全治愈耐药细菌感染的伤口，并且可以成为一种有效的生物相容性材料，用于治疗慢性伤口的化学光热疗法。此外，我们制备polyMOF杂化物的策略可能为多功能凝胶的开发提供一种通用方法，在临床应用中具有重要意义。