New insights into IRE1α activation and function in anti-tumor immunity,Journal of Cell Biology

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New insights into IRE1α activation and function in anti-tumor immunity
Journal of Cell Biology ( IF 7.4 ) Pub Date : 2022-05-11 , DOI: 10.1083/jcb.202205019
Susan E Logue _{1,

2} , Adrienne M Gorman _{3,

4,

5} , Afshin Samali _{3,

4,

5}

Affiliation

Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells.

中文翻译：

IRE1α 激活和抗肿瘤免疫功能的新见解

Logue、Gorman 和 Samali 重点介绍了 Guttman 及其同事的一项研究 (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111068)，该研究表明导入 ER 的外源抗原肽可以激活 ER 应激传感器IRE1α，减弱树突状细胞的交叉呈递。

更新日期：2022-05-11

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