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Validation of Abbreviated Form of the Multidimensional Prognostic Index (MPI): The BRIEF-MPI Project
Clinical Interventions in Aging ( IF 3.6 ) Pub Date : 2022-05-12 , DOI: 10.2147/cia.s355801 Alberto Cella 1 , Nicola Veronese 2 , Carlo Custodero 3 , Alberto Castagna 4 , Lisa A Cammalleri 1 , Walter M Capitano 2 , Luisa Solimando 2 , Luca Carruba 2 , Carlo Sabbà 3 , Giovanni Ruotolo 4 , Mario Barbagallo 2 , Alberto Pilotto 1, 3
Clinical Interventions in Aging ( IF 3.6 ) Pub Date : 2022-05-12 , DOI: 10.2147/cia.s355801 Alberto Cella 1 , Nicola Veronese 2 , Carlo Custodero 3 , Alberto Castagna 4 , Lisa A Cammalleri 1 , Walter M Capitano 2 , Luisa Solimando 2 , Luca Carruba 2 , Carlo Sabbà 3 , Giovanni Ruotolo 4 , Mario Barbagallo 2 , Alberto Pilotto 1, 3
Affiliation
Purpose: To screen multidimensional frailty in older people, using a comprehensive geriatric assessment (CGA) tool such as the multidimensional prognostic index (MPI), is a public health priority. Unfortunately, the screening tools available are not able to capture multidimensional frailty. In this work, we aimed to evaluate in a population of hospitalized and ambulatory older patients, the agreement between an abbreviated form of the MPI (ie, BRIEF-MPI) and the standard/full version.
Participants and Methods: All participants included in the study completed both versions of the MPI, brief and full, which share the following domains: 1) basic and 2) instrumental activities of daily living, 3) mobility/risk of pressure sores, 4) cognition, 5) nutrition, 6) comorbidity, 7) social and 8) number of medications. The agreement between the two instruments was reported using either the mean comparisons with a t-test matched sample, a simple correlation analysis and the Bland–Altman methodology.
Results: The study sample included 110 participants (mean age=83.2 years, 51.8% women). The mean difference was statistically and clinically irrelevant (mean difference=0.01± 0.10; p=0.27). The correlation between brief and full MPI versions was optimal (R=0.82, p< 0.0001). Using the Bland–Altman methodology, we observed that only three participants over 110 (=2.73%) were outside the limits of agreement. The accuracy of BRIEF-MPI in predicting multidimensional frailty, as full MPI> 0.66, was optimal (area under the curve=0.92, p< 0.0001). A BRIEF-MPI value of 0.59 yielded the highest sensitivity and specificity in predicting multidimensional frailty.
Conclusion: BRIEF-MPI had a good agreement with the full/standard version of the MPI, making this tool as ideal for the screening of multidimensional frailty in older people.
Keywords: multidimensional prognostic index, screening, frailty, agreement
中文翻译：
验证多维预后指数 (MPI) 的缩写形式：BRIEF-MPI 项目
目的：使用多维预后指数 (MPI) 等综合老年评估 (CGA) 工具筛查老年人的多维衰弱是一项公共卫生优先事项。不幸的是，可用的筛选工具无法捕捉多维脆弱性。在这项工作中，我们旨在评估住院和门诊老年患者群体中 MPI 的缩写形式（即，BRIEF-MPI）与标准/完整版本之间的一致性。
参与者和方法：研究中包括的所有参与者都完成了 MPI 的两个版本，简要版和完整版，它们共享以下领域：1）基本和 2）日常生活的工具性活动，3）流动性/压疮风险，4）认知，5）营养，6) 合并症，7) 社会和 8) 药物数量。使用与t检验匹配样本的平均比较、简单的相关分析和 Bland-Altman 方法来报告两种仪器之间的一致性。
结果：研究样本包括 110 名参与者（平均年龄 = 83.2 岁，51.8% 为女性）。平均差异在统计学和临床上不相关（平均差异=0.01±0.10；p=0.27）。简短和完整 MPI 版本之间的相关性是最佳的（R = 0.82，p < 0.0001）。使用 Bland-Altman 方法，我们观察到只有 110 岁以上的三名参与者 (=2.73%) 超出协议范围。BRIEF-MPI 在预测多维衰弱方面的准确度是最佳的，全 MPI>0.66（曲线下面积=0.92，p<0.0001）。0.59 的 BRIEF-MPI 值在预测多维虚弱方面具有最高的敏感性和特异性。
结论：Brief-MPI 与 MPI 的完整/标准版本有很好的一致性，使该工具成为筛查老年人多维虚弱的理想工具。
关键词：多维预后指数，筛查，虚弱，一致性
更新日期：2022-05-12
Participants and Methods: All participants included in the study completed both versions of the MPI, brief and full, which share the following domains: 1) basic and 2) instrumental activities of daily living, 3) mobility/risk of pressure sores, 4) cognition, 5) nutrition, 6) comorbidity, 7) social and 8) number of medications. The agreement between the two instruments was reported using either the mean comparisons with a t-test matched sample, a simple correlation analysis and the Bland–Altman methodology.
Results: The study sample included 110 participants (mean age=83.2 years, 51.8% women). The mean difference was statistically and clinically irrelevant (mean difference=0.01± 0.10; p=0.27). The correlation between brief and full MPI versions was optimal (R=0.82, p< 0.0001). Using the Bland–Altman methodology, we observed that only three participants over 110 (=2.73%) were outside the limits of agreement. The accuracy of BRIEF-MPI in predicting multidimensional frailty, as full MPI> 0.66, was optimal (area under the curve=0.92, p< 0.0001). A BRIEF-MPI value of 0.59 yielded the highest sensitivity and specificity in predicting multidimensional frailty.
Conclusion: BRIEF-MPI had a good agreement with the full/standard version of the MPI, making this tool as ideal for the screening of multidimensional frailty in older people.
Keywords: multidimensional prognostic index, screening, frailty, agreement
中文翻译：
验证多维预后指数 (MPI) 的缩写形式：BRIEF-MPI 项目
目的：使用多维预后指数 (MPI) 等综合老年评估 (CGA) 工具筛查老年人的多维衰弱是一项公共卫生优先事项。不幸的是，可用的筛选工具无法捕捉多维脆弱性。在这项工作中，我们旨在评估住院和门诊老年患者群体中 MPI 的缩写形式（即，BRIEF-MPI）与标准/完整版本之间的一致性。
参与者和方法：研究中包括的所有参与者都完成了 MPI 的两个版本，简要版和完整版，它们共享以下领域：1）基本和 2）日常生活的工具性活动，3）流动性/压疮风险，4）认知，5）营养，6) 合并症，7) 社会和 8) 药物数量。使用与t检验匹配样本的平均比较、简单的相关分析和 Bland-Altman 方法来报告两种仪器之间的一致性。
结果：研究样本包括 110 名参与者（平均年龄 = 83.2 岁，51.8% 为女性）。平均差异在统计学和临床上不相关（平均差异=0.01±0.10；p=0.27）。简短和完整 MPI 版本之间的相关性是最佳的（R = 0.82，p < 0.0001）。使用 Bland-Altman 方法，我们观察到只有 110 岁以上的三名参与者 (=2.73%) 超出协议范围。BRIEF-MPI 在预测多维衰弱方面的准确度是最佳的，全 MPI>0.66（曲线下面积=0.92，p<0.0001）。0.59 的 BRIEF-MPI 值在预测多维虚弱方面具有最高的敏感性和特异性。
结论：Brief-MPI 与 MPI 的完整/标准版本有很好的一致性，使该工具成为筛查老年人多维虚弱的理想工具。
关键词：多维预后指数，筛查，虚弱，一致性
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