Adhesions are dense, fibrous bridges that adjoin tissue surfaces due to uncontrolled inflammation following postoperative mesothelial injury. A widely used adhesion barrier material in Seprafilm often fails to prevent transverse scar tissue deposition because of its poor mechanical properties, rapid degradation profile, and difficulty in precise application. Solution blow spinning (SBS), a polymer fiber deposition technique, allows for the placement of in situ tissue-conforming and tissue-adherent scaffolds with exceptional mechanical properties. While biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) have desirable strength, they exhibit bulk biodegradation rates and inflammatory profiles that limit their use as adhesion barriers and result in poor tissue adhesion. Here, viscoelastic poly(lactide-co-caprolactone) (PLCL) is used for its pertinent biodegradation mechanism. Because it degrades via surface erosion, spray deposited PLCL fibers can dissolve new connections formed by inflamed tissue, allowing them to function as an effective, durable, and easy-to-apply adhesion barrier. Degradation kinetics are tuned to match adhesion formation through the design of PLCL blends comprised of highly adhesive “low”-molecular weight (LMW) constituents in a mechanically robust “high”-molecular weight (HMW) matrix. In vitro studies demonstrate that blending LMW PLCL (30% w/v) with HMW PLCL (70% w/v) yields an anti-fibrotic yet tissue-adhesive polymer sealant with a 14-day erosion rate countering adhesion formation. PLCL blends additionally exhibit improved wet tissue adhesion strength (~10 kPa) over a 14-day period versus previously explored biodegradable polymer compositions, such as PLGA. In a mouse cecal ligation model, select PLCL blends significantly reduce abdominal adhesions severity versus no treatment and Seprafilm-treated controls.

中文翻译：

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具有生物降解性的可喷涂组织粘合剂，可预防术后腹部粘连


粘连是由于术后间皮损伤后不受控制的炎症而邻接组织表面的致密纤维桥。 Seprafilm 中广泛使用的防粘连材料通常无法防止横向疤痕组织沉积，因为其机械性能差、降解速度快且难以精确应用。溶液吹纺 (SBS) 是一种聚合物纤维沉积技术，可以在原位放置具有卓越机械性能的组织顺应性和组织粘附支架。虽然聚乳酸-乙醇酸 (PLGA) 等可生物降解聚合物具有理想的强度，但它们表现出的大量生物降解率和炎症特征限制了它们作为粘连屏障的用途，并导致组织粘连不良。在这里，粘弹性聚（丙交酯-己内酯）（PLCL）因其相关的生物降解机制而被使用。由于它会通过表面侵蚀而降解，因此喷射沉积的 PLCL 纤维可以溶解发炎组织形成的新连接，使其能够充当有效、耐用且易于使用的粘连屏障。通过设计 PLCL 共混物，调整降解动力学以匹配粘附形成，该共混物由机械坚固的“高”分子量 (HMW) 基质中的高粘附性“低”分子量 (LMW) 成分组成。体外研究表明，将 LMW PLCL (30% w/v) 与 HMW PLCL (70% w/v) 混合可产生抗纤维化且具有组织粘附性的聚合物密封剂，其 14 天侵蚀率可抵抗粘连形成。与之前探索的可生物降解聚合物组合物（例如 PLGA）相比，PLCL 共混物在 14 天的时间内还表现出改善的湿组织粘合强度（约 10 kPa）。 在小鼠盲肠结扎模型中，与未处理和经过 Seprafilm 处理的对照相比，选择 PLCL 混合物可显着降低腹部粘连的严重程度。