An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields.

中文翻译：

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透明质酸接枝共聚物的点击化学交联

通过透明质酸 ( HA ) 的点击化学 (click-crosslinking) 开发了一种简单可行的交联程序。特别是，通过使用六（乙二醇）间隔物的点击化学交联，利用了显示低和中等分子量值的基于透明质烷的HA - FA - Pg接枝共聚物的可点击炔丙基基团。根据交联度，所得的HA-FA-HEG-CL材料显示出明显缺乏体外细胞毒性作用、可调节的水亲和力和流变特性，这表明它们在不同的生物医学领域中的适用性。