Correct segregation of chromosomes during mitosis is essential to prevent aneuploidy. In this issue, Ferrandiz et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203021) show that endomembranes can promote chromosome missegregation by “ensheathing” misaligned chromosomes, preventing their integration into the metaphase plate. Their findings point toward endomembranes as a potential risk factor for aneuploidy.

中文翻译：

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距离太近不舒服？内膜通过封闭丢失的染色体来促进错误分离

有丝分裂期间染色体的正确分离对于防止非整倍体至关重要。在本期中，费朗迪斯等人。 (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203021)表明内膜可以通过“包裹”错位的染色体来促进染色体错误分离，防止它们整合到中期板中。他们的发现表明内膜是非整倍体的潜在危险因素。