Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack of an effective pharmacological treatment highlights the need for a more thorough understanding of the factors that regulate the remodeling of the aortic wall in response to triggers that lead to aneurysm formation. This task is further complicated by the regional heterogeneity of the aorta and that thoracic and abdominal aortic aneurysm are distinct pathologies with different risk factors and distinct course of progression. ADAMs (a disintegrin and metalloproteinases) and ADAMTS (ADAMs with a thrombospondin motif) are proteinases that share similarities with other proteinases but possess unique and diverse properties that place them in a category of their own. In this review, we discuss what is known on how ADAMs and ADAMTSs are altered in abdominal aortic aneurysm and thoracic aortic aneurysm in patients, in different animal models, and their role in regulating the function of different vascular and inflammatory cell types. A full understanding of the role of ADAMs and ADAMTSs in aortic aneurysm will help reveal a more complete understanding of the underlying mechanism driving aneurysm formation, which will help towards developing an effective treatment in preventing or limiting the growth of aortic aneurysm.

中文翻译：

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主动脉瘤中的解整合素和金属蛋白酶（ADAM [解整合素和金属蛋白酶] 和 ADAMTS [具有血小板反应蛋白基序的 ADAM]）

主动脉瘤是一种复杂的病理学，如果不及时发现可能致命。尽管已确定多种分子机制和途径参与主动脉瘤的发展和生长，但目前缺乏有效的药物治疗凸显了需要更彻底地了解调节主动脉壁重塑以响应触发因素的因素从而导致动脉瘤的形成。由于主动脉的区域异质性以及胸主动脉瘤和腹​​主动脉瘤是具有不同危险因素和不同进展过程的不同病理，使这项任务变得更加复杂。ADAM（一种解整合素和金属蛋白酶）和 ADAMTS（具有血小板反应蛋白基序的 ADAM）是与其他蛋白酶具有相似性的蛋白酶，但具有独特且多样化的特性，使它们自成一类。在这篇综述中，我们讨论了 ADAM 和 ADAMTS 在不同动物模型中腹主动脉瘤和胸主动脉瘤患者中如何改变，以及它们在调节不同血管和炎症细胞类型功能中的作用。充分了解 ADAM 和 ADAMTS 在主动脉瘤中的作用将有助于更全面地了解驱动动脉瘤形成的潜在机制，这将有助于开发预防或限制主动脉瘤生长的有效治疗方法。我们讨论了 ADAM 和 ADAMTS 在不同动物模型中腹主动脉瘤和胸主动脉瘤患者中如何改变的已知情况，以及它们在调节不同血管和炎症细胞类型功能中的作用。充分了解 ADAM 和 ADAMTS 在主动脉瘤中的作用将有助于更全面地了解驱动动脉瘤形成的潜在机制，这将有助于开发预防或限制主动脉瘤生长的有效治疗方法。我们讨论了 ADAM 和 ADAMTS 在不同动物模型中腹主动脉瘤和胸主动脉瘤患者中如何改变的已知情况，以及它们在调节不同血管和炎症细胞类型功能中的作用。充分了解 ADAM 和 ADAMTS 在主动脉瘤中的作用将有助于更全面地了解驱动动脉瘤形成的潜在机制，这将有助于开发预防或限制主动脉瘤生长的有效治疗方法。