Probiotics are an eco-friendly alternative to antibiotics and play an important role in ensuring the sustainability of aquaculture. The aim of the present study was to investigate the effects of Saccharomyces cerevisiae on the growth, intestinal and liver health, intestinal microbiota, and disease resistance of channel catfish (Ictalurus punctatus). Channel catfish were randomly allotted into two treatments, control group (basal diet) and SCC group (basal diet with 2% Saccharomyces cerevisiae culture), and fed for 12 weeks. The results showed that the weight gain of SCC group was significantly increased (P < 0.05) and FCR was significantly decreased (P < 0.05) when compared with the control group. SCC diet significantly improved the intestinal structural integrity of channel catfish and increased the number of intestinal goblet cell. The expression of intestinal gene HIF1α was increased in SCC group, while the expressions of NF-κB in the intestine and liver were significantly decreased (P < 0.05). The relative abundance of Firmicutes tended to increase, while Proteobacteria had a tendency to decrease (0.20 > P > 0.05). In addition, the survival rate of channel catfish was significantly increased in SCC group after being challenged with mixture of A. veronii HM091 and A. hydrophila NJ-1. In conclusion, the supplementation of Saccharomyces cerevisiae culture improved the growth, intestinal and liver health and disease resistance of channel catfish.

益生菌是抗生素的环保替代品，在确保水产养殖的可持续性方面发挥着重要作用。本研究的目的是研究酿酒酵母对鲶鱼 ( Ictalurus punctatus ) 的生长、肠道和肝脏健康、肠道微生物群和抗病性的影响。将鲶鱼随机分为两个处理组，对照组（基础日粮）和SCC组（基础日粮加2%酿酒酵母培养物），饲养12周。结果显示，SCC组体重增加显着增加（P  < 0.05），FCR显着降低（P < 0.05) 与对照组相比。SCC日粮显着改善了鲶鱼的肠道结构完整性，增加了肠道杯状细胞的数量。SCC组肠道基因HIF1α表达升高，而肠道和肝脏NF-κB表达明显降低（P  < 0.05）。厚壁菌门的相对丰度有增加的趋势，而变形菌门的相对丰度有降低的趋势（0.20 >  P  > 0.05）。此外，SCC 组鲶鱼的存活率在受到维罗尼HM091 和A.hydrophila NJ-1 的混合攻击后显着提高。总之，补充酿酒酵母培养改善了鲶鱼的生长、肠道和肝脏健康以及抗病性。