The brutal toll of another viral pandemic can be blunted by investing now in research that uncovers mechanisms of broad-based immunity so we may have vaccines and therapeutics at the ready. We do not know exactly what pathogen may trigger the next wave or next pandemic. We do know, however, that the human immune system must respond and must be bolstered with effective vaccines and other therapeutics to preserve lives and livelihoods. These countermeasures must focus on features conserved among families of pathogens in order to be responsive against something yet to emerge. Here, we focus on immunological approaches to mitigate the impact of the next emerging virus pandemic by developing vaccines that elicit both broadly protective antibodies and T cells. Identifying human immune mechanisms of broad protection against virus families with pandemic potential will be our best defense for humanity in the future.

现在投资于揭示广泛免疫机制的研究，可以减轻另一场病毒大流行造成的残酷损失，这样我们就可以准备好疫苗和治疗方法。我们并不确切知道什么病原体可能引发下一波或下一次大流行。然而，我们确实知道，人类免疫系统必须做出反应，并且必须得到有效的疫苗和其他疗法的支持，以保护生命和生计。这些对策必须关注病原体家族中保守的特征，以便对尚未出现的问题做出反应。在这里，我们重点关注免疫学方法，通过开发能够引发广泛保护性抗体和 T 细胞的疫苗来减轻下一次新出现的病毒大流行的影响。