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A coumarin coupled tetraphenylethylene based multi-targeted AIEgen for cyanide ion and nitro explosive detection, and cellular imaging
Analyst ( IF 3.6 ) Pub Date : 2022-05-10 , DOI: 10.1039/d2an00040g Viraj G Naik 1 , Sharanabasava D Hiremath 1 , Ankit Thakuri 1 , Vijay Hemmadi 2 , Malabika Biswas 2 , Mainak Banerjee 1 , Amrita Chatterjee 1
Analyst ( IF 3.6 ) Pub Date : 2022-05-10 , DOI: 10.1039/d2an00040g Viraj G Naik 1 , Sharanabasava D Hiremath 1 , Ankit Thakuri 1 , Vijay Hemmadi 2 , Malabika Biswas 2 , Mainak Banerjee 1 , Amrita Chatterjee 1
Affiliation
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A coumarin coupled tetraphenylethylene based AIEgen (TPE-Lac) with an intense greenish-yellow emission has been synthesized and utilized for multipurpose sensing and imaging applications. TPE-Lac acts as a sensitive sensor for the detection of cyanide ions (CN−) with an immediate turn-off response in the presence of many other interfering cations and anions. The limit of detection (LOD) was as low as 33 nM, which is well below the permissible limit set by the World Health Organization (WHO). Cyanide detection in the solid phase was successfully demonstrated by drop-casting the solution of the TPE-Lac probe on TLC plates and measuring and analysing the fluorescence response by ImageJ analysis. TPE-Lac was further employed in the detection of explosive nitroaromatics in solution and solid phases. Also, TPE-Lac was found suitable as an imaging agent and could easily percolate into live H520 cells giving bright fluorescence from the intra-cellular region. Easy and cost-effective synthesis, fast response and low LODs are some of the advantages of this AIEgen over available molecular probes for the same purpose.
中文翻译：
一种基于香豆素偶联四苯基乙烯的多靶点 AIEgen，用于氰化物离子和硝基爆炸物检测和细胞成像
已合成具有强烈黄绿色发射的香豆素偶联四苯基乙烯基 AIEgen ( TPE-Lac )，并用于多用途传感和成像应用。TPE-Lac用作检测氰化物离子 (CN - ) 的灵敏传感器，在存在许多其他干扰性阳离子和阴离子的情况下具有立即关闭响应。检测限 (LOD) 低至 33 nM，远低于世界卫生组织 (WHO) 设定的允许限值。通过将TPE-Lac探针溶液滴注在 TLC 板上并通过 ImageJ 分析测量和分析荧光响应，成功地证明了固相中的氰化物检测。TPE-紫胶进一步用于检测溶液和固相中的爆炸性硝基芳烃。此外，发现TPE-Lac适合作为显像剂，并且可以很容易地渗透到活的 H520 细胞中，从细胞内区域发出明亮的荧光。简单且具有成本效益的合成、快速响应和低 LOD 是该 AIEgen 优于用于相同目的的可用分子探针的一些优势。
更新日期：2022-05-10
中文翻译：
一种基于香豆素偶联四苯基乙烯的多靶点 AIEgen，用于氰化物离子和硝基爆炸物检测和细胞成像
已合成具有强烈黄绿色发射的香豆素偶联四苯基乙烯基 AIEgen ( TPE-Lac )，并用于多用途传感和成像应用。TPE-Lac用作检测氰化物离子 (CN - ) 的灵敏传感器，在存在许多其他干扰性阳离子和阴离子的情况下具有立即关闭响应。检测限 (LOD) 低至 33 nM，远低于世界卫生组织 (WHO) 设定的允许限值。通过将TPE-Lac探针溶液滴注在 TLC 板上并通过 ImageJ 分析测量和分析荧光响应，成功地证明了固相中的氰化物检测。TPE-紫胶进一步用于检测溶液和固相中的爆炸性硝基芳烃。此外，发现TPE-Lac适合作为显像剂，并且可以很容易地渗透到活的 H520 细胞中，从细胞内区域发出明亮的荧光。简单且具有成本效益的合成、快速响应和低 LOD 是该 AIEgen 优于用于相同目的的可用分子探针的一些优势。
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