Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating,Lab on a Chip

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Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-05-11 , DOI: 10.1039/d2lc00196a
Ji-Won Kim ₁ , Sang Hoon Han ₁ , Ye Hun Choi ₁ , Wahyu Martumpal Hamonangan ₁ , Yoonjin Oh ₁ , Shin-Hyun Kim ₁

Affiliation

Multiple-emulsion drops serve as versatile templates to design functional microcapsules due to their core–shell geometry and multiple compartments. Microfluidics has been used for the elaborate production of multiple-emulsion drops with a controlled composition, order, and dimensions, elevating the value of multiple-emulsion templates. Moreover, recent advances in the microfluidic control of the emulsification and parallelization of drop-making junctions significantly enhance the production throughput for practical use. Metastable multiple-emulsion drops are converted into stable microcapsules through the solidification of selected phases, among which solid shells are designed to function in a programmed manner. Functional microcapsules are used for the storage and release of active materials as drug carriers. Beyond their conventional uses, microcapsules can serve as microcompartments responsible for transmembrane communication, which is promising for their application in advanced microreactors, artificial cells, and microsensors. Given that post-processing provides additional control over the composition and construction of multiple-emulsion drops, they are excellent confining geometries to study the self-assembly of colloids and liquid crystals and produce miniaturized photonic devices. This review article presents the recent progress and current state of the art in the microfluidic production of multiple-emulsion drops, functionalization of solid shells, and applications of microcapsules.

中文翻译：

多重乳液模板微流控生产功能性微胶囊的最新进展

由于其核壳几何形状和多个隔室，多重乳液滴剂可用作设计功能性微胶囊的通用模板。微流体已被用于精心生产具有受控成分、顺序和尺寸的多乳液液滴，从而提升了多乳液模板的价值。此外，最近在微流体控制滴液连接的乳化和平行化方面取得的进展显着提高了实际应用的生产吞吐量。亚稳态多重乳液液滴通过选定相的固化转化为稳定的微胶囊，其中固体壳被设计为以编程方式发挥作用。功能性微胶囊作为药物载体用于活性物质的储存和释放。除了它们的常规用途，微胶囊可作为负责跨膜通讯的微隔室，有望在先进的微反应器、人工细胞和微传感器中得到应用。鉴于后处理提供了对多乳液液滴的组成和构造的额外控制，它们是研究胶体和液晶自组装和生产小型光子器件的极好限制几何形状。这篇综述文章介绍了多乳液滴微流控生产、固体壳的功能化和微胶囊应用方面的最新进展和现有技术。鉴于后处理提供了对多乳液液滴的组成和构造的额外控制，它们是研究胶体和液晶自组装和生产小型光子器件的极好限制几何形状。这篇综述文章介绍了多乳液滴微流控生产、固体壳的功能化和微胶囊应用方面的最新进展和现有技术。鉴于后处理提供了对多乳液液滴的组成和构造的额外控制，它们是研究胶体和液晶自组装和生产小型光子器件的极好限制几何形状。这篇综述文章介绍了多乳液滴微流控生产、固体壳的功能化和微胶囊应用方面的最新进展和现有技术。

更新日期：2022-05-11

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