Exploiting Wavelength Orthogonality in Photoinitiated RAFT Dispersion Polymerization and Photografting for Monodisperse Surface-Functional Polymeric Microspheres,ACS Macro Letters

当前位置： X-MOL 学术 › ACS Macro Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Exploiting Wavelength Orthogonality in Photoinitiated RAFT Dispersion Polymerization and Photografting for Monodisperse Surface-Functional Polymeric Microspheres
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-05-10 , DOI: 10.1021/acsmacrolett.2c00228
Kunlun Zhang ₁ , Mingheng Xiao ₁ , Li Zhang _{1,

2} , Ying Chen ₂ , Jianbo Tan _{1,

2}

Affiliation

We report a strategy toward surface-functional polymeric microspheres using a wavelength orthogonality technique that employs photoinitiated reversible addition–fragmentation chain transfer (RAFT) dispersion polymerization and the subsequent photografting under different wavelengths of light. Initial screening of reaction conditions indicated photoreactive polymeric microsphere with uniform sizes could be prepared by using photoinitiator-functionalized macro-RAFT agents under purple light irradiation. Photoreactive polymeric microspheres allowed photografting polymerizations under UV light irradiation, and we further demonstrated the broad scope of this method by photografting acrylamide, acrylic, and methacrylic monomers. Finally, carboxyl-functionalized polymeric microspheres with an exceptional high number of carboxyl groups were successfully prepared by this technique, which permitted extensive surface bioconjugation of model proteins (e.g., streptavidin). This method should expand the capabilities of RAFT dispersion polymerization to afford diverse surface-functional polymeric microspheres for some specific applications.

中文翻译：

利用光引发 RAFT 分散聚合和光接枝中的波长正交性制备单分散表面功能聚合物微球

我们报告了一种使用波长正交技术制备表面功能聚合物微球的策略，该技术采用光引发的可逆加成-断裂链转移 (RAFT) 分散聚合和随后在不同波长的光下的光接枝。反应条件的初步筛选表明，在紫光照射下，使用光引发剂功能化的大分子RAFT剂可以制备尺寸均匀的光反应聚合物微球。光反应性聚合物微球允许在紫外光照射下进行光接枝聚合，我们通过光接枝丙烯酰胺、丙烯酸和甲基丙烯酸单体进一步证明了该方法的广泛范围。最后，通过该技术成功地制备了具有异常大量羧基的羧基官能化聚合物微球，这允许模型蛋白（例如链霉抗生物素蛋白）的广泛表面生物缀合。该方法应扩展 RAFT 分散聚合的能力，为某些特定应用提供多种表面功能聚合物微球。

更新日期：2022-05-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11