Tear secretion is regulated by the lacrimal functional unit consisting of afferent and efferent nerve innervation. The afferent arm consists of trigeminal nociceptors on the ocular surface and nasal mucosa. When stimulated by agonists, nicotinic acetylcholine receptors on nerve endings in the nose initiate a reflex arc resulting in instantaneous tear secretion. Pharmacologic nasal neural stimulation to increase endogenous tear production is a novel approach to treating dry eye disease.

中文翻译：

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烟碱型乙酰胆碱受体刺激：刺激干眼症泪液分泌的新方法

泪液分泌受泪腺功能单元的调节，该单元由传入和传出神经支配组成。传入臂由眼表和鼻粘膜上的三叉神经痛觉感受器组成。当被激动剂刺激时，鼻子神经末梢上的烟碱型乙酰胆碱受体启动反射弧，导致瞬时泪液分泌。增加内源性泪液产生的药物鼻神经刺激是治疗干眼症的新方法。