The aim of this study was to investigate the therapeutic effect of JQ-R on metabolic hypertension and its correlation with Fibroblast growth factor 21/Fibroblast growth factor receptors 1(FGF21/FGFR1) pathway. In this study, fructose-induced metabolic hypertension rats were used as hypertension models to detect the regulation effect of JQ-R on hypertension. The effects of JQ-R on blood glucose, blood lipids, serum insulin levels and other metabolic indicators of rats were also measured. The effects of JQ-R on FGF21/FGFR1 signaling pathway in model animals were detected by Real-time quantitative PCR and Western blotting. The results showed that JQ-R significantly reduce the blood pressure of model rats in a dose-dependent manner. Meanwhile, fasting insulin, fasting blood glucose, insulin resistance index, total cholesterol and triglyceride levels were significantly decreased, and glucose and lipid metabolism abnormalities were also significantly improved. JQ-R induces these changes along with FGFR1 phosphorylation, which was also detected in JQ-R treated FGF21 knockout mice. These results suggest that JQ-R can reduce blood pressure and improve glucose and lipid metabolism in fructose-induced hypertension rats. Activation of FGF21/FGFR1 signaling pathway to regulate downstream blood pressure and glucolipid metabolism-related pathways may be one of the important mechanisms of JQ-R in regulating blood pressure.

本研究旨在探讨JQ-R对代谢性高血压的治疗作用及其与成纤维细胞生长因子21/成纤维细胞生长因子受体1(FGF21/FGFR1)通路的相关性。本研究以果糖诱导的代谢性高血压大鼠为高血压模型，检测JQ-R对高血压的调节作用。还测定了JQ-R对大鼠血糖、血脂、血清胰岛素水平等代谢指标的影响。采用实时定量PCR和Western blotting检测JQ-R对模型动物FGF21/FGFR1信号通路的影响。结果表明，JQ-R以剂量依赖性方式显着降低模型大鼠的血压。同时，空腹胰岛素、空腹血糖、胰岛素抵抗指数、总胆固醇和甘油三酯水平明显下降，糖脂代谢异常也明显改善。JQ-R 与 FGFR1 磷酸化一起诱导这些变化，这也在 JQ-R 处理的 FGF21 敲除小鼠中检测到。这些结果表明，JQ-R可以降低果糖诱导的高血压大鼠的血压并改善糖脂代谢。激活FGF21/FGFR1信号通路调节下游血压及糖脂代谢相关通路可能是JQ-R调节血压的重要机制之一。这些结果表明，JQ-R可以降低果糖诱导的高血压大鼠的血压并改善糖脂代谢。激活FGF21/FGFR1信号通路调节下游血压及糖脂代谢相关通路可能是JQ-R调节血压的重要机制之一。这些结果表明，JQ-R可以降低果糖诱导的高血压大鼠的血压并改善糖脂代谢。激活FGF21/FGFR1信号通路调节下游血压及糖脂代谢相关通路可能是JQ-R调节血压的重要机制之一。