Background:Achieving healthy vascular aging (HVA) is important for decelerating age-related cardiovascular disease risk. We evaluated the interplay between HVA, cardiorespiratory fitness (CRF), and subclinical atherosclerosis.Methods:We analyzed data on 3722 men who underwent cardiopulmonary exercise testing in a health examination program. HVA was defined as blood pressure <140/90 mm Hg without hypertension and brachial-ankle pulse wave velocity <1266 cm/s. CRF was directly measured by peak oxygen uptake. Subclinical atherosclerosis was defined as coronary artery calcification scores of >0 and ≥100 and a mean carotid artery intima-media thickness (CIMT) >75th percentile for each age group as well as >0.8 mm of CIMT. Separate and joint associations of HVA and CRF with subclinical atherosclerosis were evaluated.Results:Each 1 metabolic equivalent increment in CRF was associated with 23% higher odds for having HVA. HVA was associated with lower odds of coronary artery calcification but not CIMT. CRF modified the association between HVA and CIMT>0.8 mm (interaction: P=0.01); HVA was associated with lower odds of CIMT>0.8 mm in fit men with no significant association between HVA and CIMT>0.8 mm in unfit men. Compared with no HVA and being unfit, HVA and being fit was associated with lower odds of subclinical atherosclerosis, but there was no significant association between HVA and being unfit with subclinical atherosclerosis.Conclusions:HVA and higher CRF are each associated with a lower risk of subclinical atherosclerosis in men. Higher CRF is associated with a higher prevalence of HVA and may modify the association between HVA and subclinical atherosclerosis.

中文翻译：

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心肺健康和健康血管老化与男性亚临床动脉粥样硬化的单独和联合关联

背景：实现健康的血管老化 (HVA) 对于降低与年龄相关的心血管疾病风险很重要。我们评估了 HVA、心肺健康 (CRF) 和亚临床动脉粥样硬化之间的相互作用。方法：我们分析了在健康检查项目中接受心肺运动测试的 3722 名男性的数据。HVA定义为血压<140/90 mm Hg，无高血压且臂踝脉搏波速度<1266 cm/s。CRF 直接通过峰值摄氧量来测量。亚临床动脉粥样硬化定义为冠状动脉钙化评分 > 0 和 ≥ 100，每个年龄组的平均颈动脉内膜中层厚度 (CIMT) > 75% 以及 > 0.8 mm CIMT。评估了 HVA 和 CRF 与亚临床动脉粥样硬化的单独和联合关联。 结果：CRF 中每增加 1 个代谢当量，患 HVA 的几率就会增加 23%。HVA 与较低的冠状动脉钙化几率相关，但与 CIMT 无关。CRF 修改了 HVA 和 CIMT>0.8 mm 之间的关联（相互作用：P = 0.01); HVA 与健康男性 CIMT>0.8 mm 的几率较低相关，而 HVA 与不健康男性 CIMT>0.8 mm 之间没有显着关联。与无 HVA 和不适合相比，HVA 和适合与亚临床动脉粥样硬化的发生率较低相关，但 HVA 与不适合与亚临床动脉粥样硬化之间无显着相关性。结论：HVA 和较高的 CRF 均与较低的动脉粥样硬化风险相关。男性亚临床动脉粥样硬化。较高的 CRF 与较高的 HVA 患病率相关，并可能改变 HVA 与亚临床动脉粥样硬化之间的关联。