In this issue of Cancer Cell, Hanada et al. leverage single-cell multi-omics of lung cancer resident lymphocytes to identify phenotypic and transcriptomic signatures differentially expressed by neoantigen-reactive clonotypes. These findings could substantially expedite the selection of neoantigen-specific T cell receptors (TCRs) for individualized T cell therapies.

中文翻译：

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个性化 TCR T 细胞疗法的快速通道

在本期癌症细胞中，Hanada 等人。利用肺癌驻留淋巴细胞的单细胞多组学来识别由新抗原反应性克隆型差异表达的表型和转录组特征。这些发现可以大大加快个体化 T 细胞疗法的新抗原特异性 T 细胞受体 (TCR) 的选择。